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dc.contributor.authorSun, Qi
dc.contributor.authorvan Dam, Rob M.
dc.contributor.authorWillett, Walter C.
dc.contributor.authorHu, Frank B.
dc.date.accessioned2011-05-19T00:37:37Z
dc.date.issued2009
dc.identifier.citationSun, Qi, Rob M. van Dam, Walter C. Willett, and Frank B. Hu. 2009. Prospective Study of Zinc Intake and Risk of Type 2 Diabetes in Women. Diabetes Care 32(4): 629-634.en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4891660
dc.description.abstractOBJECTIVE: The aim of this study is to investigate the intake of zinc in relation to risk of type 2 diabetes in U.S. women. RESEARCH DESIGN AND METHODS: Dietary intakes of zinc and other nutrients were assessed and updated using a validated food frequency questionnaire from 1980 to 2002 among 82,297 women who were aged 33–60 years at baseline in 1980 and followed up to 2004 in the Nurses' Health Study. RESULTS: During the 24 years of follow-up, 6,030 incident cases of type 2 diabetes were ascertained. After adjustment of lifestyle and dietary risk factors, the relative risks (RRs) (95% CI) of type 2 diabetes comparing the highest with the lowest quintiles were 0.90 (0.82–0.99) (Ptrend = 0.04) for total zinc intake and 0.92 (0.84–1.00) (Ptrend = 0.009) for dietary zinc intake from food sources, respectively. We further found an inverse association for dietary zinc to heme iron ratio. After multivariate adjustment of covariates, the RRs (95% CI) across quintiles of this ratio were 1.0 (reference), 0.93 (0.86–1.01), 0.86 (0.79–0.94), 0.82 (0.75–0.90), and 0.72 (0.66–0.80), respectively (Ptrend < 0.0001). CONCLUSIONS: Higher zinc intake may be associated with a slightly lower risk of type 2 diabetes in women. More studies are warranted to confirm this association and to explore potential mechanisms.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionofdoi:10.2337/dc08-1913en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660459/pdf/en_US
dash.licenseLAA
dc.subjectEpidemiology/Health Services Researchen_US
dc.titleProspective Study of Zinc Intake and Risk of Type 2 Diabetes in Womenen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetes Careen_US
dash.depositing.authorvan Dam, Rob M.
dc.date.available2011-05-19T00:37:37Z
dash.affiliation.otherSPH^Nutritionen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Nutritionen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Nutritionen_US
dc.identifier.doi10.2337/dc08-1913*
dash.contributor.affiliatedVan Dam, Rob
dash.contributor.affiliatedSun, Qi
dash.contributor.affiliatedHu, Frank
dash.contributor.affiliatedWillett, Walter


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