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dc.contributor.authorWilker, Elissa Hope
dc.contributor.authorMittleman, Murray A.
dc.contributor.authorLitonjua, Augusto Ampil
dc.contributor.authorPoon, Audrey
dc.contributor.authorBaccarelli, Andrea
dc.contributor.authorSuh, Helen
dc.contributor.authorWright, Robert O.
dc.contributor.authorSparrow, David
dc.contributor.authorVokonas, Pantel S
dc.contributor.authorSchwartz, Joel David
dc.date.accessioned2011-05-19T00:47:13Z
dc.date.issued2009
dc.identifier.citationWilker, Elissa, Murray A. Mittleman, Augusto A. Litonjua, Audrey Poon, Andrea Baccarelli, Helen Suh, Robert O. Wright, David Sparrow, Pantel Vokonas, and Joel Schwartz. 2009. Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter. Environmental Health Perspectives 117(6): 935-940.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4891662
dc.description.abstractBackground: Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation.Objective We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) and in diastolic blood pressure (ΔDBP) and that this effect is modified by genes thought to be related to chronic lung disease. Methods: We measured blood pressure in participants every 3–5 years. ΔSBP and ΔDBP were calculated as sitting minus standing SBP and DBP. We averaged PM2.5 over 48 hr before study visits and analyzed 202 single nucleotide polymorphisms (SNPs) in 25 genes. To address multiple comparisons, data were stratified into a split sample. In the discovery cohort, the effects of SNP × PM2.5 interactions on ΔSBP and ΔDBP were analyzed using mixed models with subject-specific random intercepts. We defined positive outcomes as p < 0.1 for the interaction; we analyzed only these SNPs in the replicate cohort and confirmed them if p < 0.025 with the same sign. Confirmed associations were analyzed within the full cohort in models adjusted for anthropometric and lifestyle factors. Results: Nine hundred forty-five participants were included in our analysis. One interaction with rs9568232 in PHD finger protein 11 (PHF11) was associated with greater ΔDBP. Interactions with rs1144393 in matrix metalloprotease 1 (MMP1) and rs16930692, rs7955200, and rs10771283 in inositol 1,4,5-triphosphate receptor, type 2 (ITPR2) were associated with significantly greater ΔSBP. Because SNPs associated with ΔSBP in our analysis are in genes along the renin–angiotensin pathway, we then examined medications affecting that pathway and observed significant interactions for angiotensin receptor blockers but not angiotensin-converting enzyme inhibitors with PM2.5. Conclusions: PM2.5 influences blood pressure and autonomic function. This effect is modified by genes and drugs that also act along this pathway.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.0800279en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702409/pdf/en_US
dash.licenseLAA
dc.subjectaging and susceptible populationsen_US
dc.subjectblood pressureen_US
dc.subjectenvironmental epidemiologyen_US
dc.subjectgene–environment interactionen_US
dc.subjectparticulate matter.en_US
dc.titlePostural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matteren_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorMittleman, Murray A.
dc.date.available2011-05-19T00:47:13Z
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dc.identifier.doi10.1289/ehp.0800279*
dash.contributor.affiliatedWilker, Elissa
dash.contributor.affiliatedWright, Robert
dash.contributor.affiliatedVokonas, Pantel
dash.contributor.affiliatedSparrow, David
dash.contributor.affiliatedMittleman, Murray
dash.contributor.affiliatedLitonjua, Augusto A.
dash.contributor.affiliatedSchwartz, Joel
dash.contributor.affiliatedBaccarelli, Andrea


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