Polymorphisms in Signal Transducer and Activator of Transcription 3 and Lung Function in Asthma

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Polymorphisms in Signal Transducer and Activator of Transcription 3 and Lung Function in Asthma

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Title: Polymorphisms in Signal Transducer and Activator of Transcription 3 and Lung Function in Asthma
Author: Lake, Stephen; Richter, Brent G; Gabriel, Stacey; Silverman, Eric S; Litonjua, Augusto Ampil; Tantisira, Kelan; Lazarus, Ross; Weiss, Scott Tillman

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Citation: Litonjua, Augusto A., Kelan G. Tantisira, Stephen Lake, Ross Lazarus, Brent G. Richter, Stacey Gabriel, Eric S. Silverman, and Scott T. Weiss. 2005. Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma. Respiratory Research 6(1): 52.
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Abstract: Background: Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis. Methods: We genotyped six single nucleotide polymorphisms (SNPs) in the STAT3 gene in a cohort of 401 Caucasian adult asthmatics. The associations between each SNP and forced expiratory volume in 1 second (FEV\(_{1}\)), as a percent of predicted, at the baseline exam were tested using multiple linear regression models. Longitudinal analyses involving repeated measures of FEV\(_{1}\) were conducted with mixed linear models. Haplotype analyses were conducted using imputed haplotypes. We completed a second association study by genotyping the same six polymorphisms in a cohort of 652 Caucasian children with asthma. Results: We found that three polymorphisms were significantly associated with baseline FEV\(_{1}\): homozygotes for the minor alleles of each polymorphism had lower FEV\(_{1}\) than homozygotes for the major alleles. Moreover, these associations persisted when we performed an analysis on repeated measures of FEV\(_{1}\) over 8 weeks. A haplotypic analysis based on the six polymorphisms indicated that two haplotypes were associated with baseline FEV\(_{1}\). Among the childhood asthmatics, one polymorphism was associated with both baseline FEV\(_{1}\) and the repeated measures of FEV\(_{1}\) over 4 years. Conclusion: Our results indicate that genetic variants in STAT3, independent of asthma treatment, are determinants of FEV\(_{1}\) in both adults and children with asthma, and suggest that STAT3 may participate in inflammatory pathways that have an impact on level of lung function.
Published Version: doi:10.1186/1465-9921-6-52
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180474/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4891680
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