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dc.contributor.authorArora, Manish
dc.contributor.authorWeuve, Jennifer Lynn
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorWright, Robert O.
dc.date.accessioned2011-05-19T20:01:51Z
dc.date.issued2009
dc.identifier.citationArora, Manish, Jennifer Weuve, Joel Schwartz, and Robert O. Wright. 2009. Association of Environmental Cadmium Exposure with Periodontal Disease in U.S. Adults. Environmental Health Perspectives 117(5): 739-744.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4892358
dc.description.abstractBackground: Periodontal disease is a complex, multifactorial, chronic inflammatory disease that involves degradation of periodontal structures, including alveolar bone. Cadmium adversely affects bone remodeling, and it is therefore possible that environmental Cd exposure may be a risk factor for periodontal-disease–related bone loss. Objective: We examined the relationship between environmental Cd exposure and periodontal disease in U.S. adults. Methods: We analyzed cross-sectional data from the third National Health and Nutrition Examination Survey (NHANES III). We defined periodontal disease as clinical attachment loss of at least 4 mm in > 10% of sites examined. We used multivariable-adjusted logistic regression analyses to estimate the association between creatinine-corrected urinary Cd levels and periodontal disease. Results: Of the 11,412 participants included in this study, 15.4% had periodontal disease. The age-adjusted geometric mean urine Cd concentration (micrograms per gram creatinine) was significantly higher among participants with periodontal disease [0.50; 95% confidence interval (CI), 0.45–0.56] than among those without periodontal disease (0.30; 95% CI, 0.28–0.31). Multivariable-adjusted analyses, which included extensive adjustments for tobacco exposure, showed that a 3-fold increase in creatinine-corrected urinary Cd concentrations [corresponding to an increment from the 25th (0.18 μg/g) to the 75th (0.63 μg/g) percentile] was associated with 54% greater odds of prevalent periodontal disease (odds ratio = 1.54; 95% CI, 1.26–1.87). We observed similar results among the subset of participants who had limited exposure to tobacco, but only after removing six influential observations. Conclusion: Environmental Cd exposure was associated with higher odds of periodontal disease.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.0800312en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685835/pdf/en_US
dash.licenseLAA
dc.subjectenvironmental tobacco smokeen_US
dc.subjectNHANES IIIen_US
dc.subjectperiodontal diseaseen_US
dc.subjectsmokingen_US
dc.subjecturine cadmiumen_US
dc.titleAssociation of Environmental Cadmium Exposure with Periodontal Disease in U.S. Adultsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorWeuve, Jennifer Lynn
dc.date.available2011-05-19T20:01:51Z
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dc.identifier.doi10.1289/ehp.0800312*
dash.contributor.affiliatedArora, Manish
dash.contributor.affiliatedWeuve, Jennifer Lynn
dash.contributor.affiliatedWright, Robert
dash.contributor.affiliatedSchwartz, Joel
dc.identifier.orcid0000-0002-2557-150X


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