Show simple item record

dc.contributor.authorClougherty, Jane E.
dc.contributor.authorLevy, Jonathan Ian
dc.contributor.authorKubzansky, Laura Diane
dc.contributor.authorRyan, P. Barry
dc.contributor.authorSuglia, Shakira Franco
dc.contributor.authorCanner, Marina Jacobson
dc.contributor.authorWright, Rosalind Jo
dc.date.accessioned2011-05-19T20:12:39Z
dc.date.issued2007
dc.identifier.citationClougherty, Jane E., Jonathan I. Levy, Laura D. Kubzansky, P. Barry Ryan, Shakira Franco Suglia, Marina Jacobson Canner, and Rosalind J. Wright. 2007. Synergistic effects of traffic-related air pollution and exposure to violence on urban asthma etiology. Environmental Health Perspectives 115(8): 1140-1146.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4892366
dc.description.abstractBackground: Disproportionate life stress and consequent physiologic alteration (i.e., immune dysregulation) has been proposed as a major pathway linking socioeconomic position, environmental exposures, and health disparities. Asthma, for example, disproportionately affects lower-income urban communities, where air pollution and social stressors may be elevated. Objectives: We aimed to examine the role of exposure to violence (ETV), as a chronic stressor, in altering susceptibility to traffic-related air pollution in asthma etiology. Methods: We developed geographic information systems (GIS)–based models to retrospectively estimate residential exposures to traffic-related pollution for 413 children in a community-based pregnancy cohort, recruited in East Boston, Massachusetts, between 1987 and 1993, using monthly nitrogen dioxide measurements for 13 sites over 18 years. We merged pollution estimates with questionnaire data on lifetime ETV and examined the effects of both on childhood asthma etiology. Results: Correcting for potential confounders, we found an elevated risk of asthma with a 1-SD (4.3 ppb) increase in NO2 exposure solely among children with above-median ETV [odds ratio (OR) = 1.63; 95% confidence interval (CI), 1.14–2.33)]. Among children always living in the same community, with lesser exposure measurement error, this association was magnified (OR = 2.40; 95% CI, 1.48–3.88). Of multiple exposure periods, year-of-diagnosis NO\(_2\) was most predictive of asthma outcomes. Conclusions: We found an association between traffic-related air pollution and asthma solely among urban children exposed to violence. Future studies should consider socially patterned susceptibility, common spatial distributions of social and physical environmental factors, and potential synergies among these. Prospective assessment of physical and social exposures may help determine causal pathways and critical exposure periods.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.9863en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940095/pdf/en_US
dash.licenseLAA
dc.subjectchildhood asthmaen_US
dc.subjectexposure to violence (ETV)en_US
dc.subjectgeographic information systems (GIS)en_US
dc.subjectintraurban variabilityen_US
dc.subjectnitrogen dioxide (NO\(_2\))en_US
dc.subjectsocial-environmental synergyen_US
dc.subjectstressen_US
dc.titleSynergistic effects of traffic-related air pollution and exposure to violence on urban asthma etiologyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorKubzansky, Laura Diane
dc.date.available2011-05-19T20:12:39Z
dash.affiliation.otherSPH^Society Human Development and Healthen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dc.identifier.doi10.1289/ehp.9863*
dash.contributor.affiliatedKubzansky, Laura
dash.contributor.affiliatedWright, Rosalind Jo
dash.contributor.affiliatedLevy, Jonathan


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record