Temporal Lobe Cortical Electrical Stimulation during the Encoding and Retrieval Phase Reduces False Memories

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Temporal Lobe Cortical Electrical Stimulation during the Encoding and Retrieval Phase Reduces False Memories

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dc.contributor.author Boggio, Paulo S.
dc.contributor.author Valasek, Claudia
dc.contributor.author Ellwood, Sophie
dc.contributor.author Gallate, Jason
dc.contributor.author Snyder, Allan
dc.contributor.author Fregni, Felipe
dc.contributor.author Chi, Richard Po-Hung
dc.contributor.author Pascual-Leone, Alvaro
dc.date.accessioned 2011-06-13T14:20:49Z
dc.date.issued 2009
dc.identifier.citation Boggio, Paulo S., Felipe Fregni, Claudia Valasek, Sophie Ellwood, Richard Chi, Jason Gallate, Alvaro Pascual-Leone, and Allan Snyder. 2009. Temporal Lobe Cortical Electrical Stimulation during the Encoding and Retrieval Phase Reduces False Memories. PLoS ONE 4(3): e4959. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4910909
dc.description.abstract A recent study found that false memories were reduced by 36% when low frequency repetitive transcranial magnetic stimulation (rTMS) was applied to the left anterior temporal lobe after the encoding (study) phase. Here we were interested in the consequences on a false memory task of brain stimulation throughout the encoding and retrieval task phases. We used transcranial direct current stimulation (tDCS) because it has been shown to be a useful tool to enhance cognition. Specifically, we examined whether tDCS can induce changes in a task assessing false memories. Based on our preliminary results, three conditions of stimulation were chosen: anodal left/cathodal right anterior temporal lobe (ATL) stimulation (“bilateral stimulation”); anodal left ATL stimulation (with a large contralateral cathodal electrode – referred as “unilateral stimulation”) and sham stimulation. Our results showed that false memories were reduced significantly after the two active conditions (unilateral and bilateral stimulation) as compared with sham stimulation. There were no significant changes in veridical memories. Our findings show that false memories are reduced by 73% when anodal tDCS is applied to the anterior temporal lobes throughout the encoding and retrieval stages, suggesting a possible strategy for improving certain aspects of learning. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0004959 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655647/pdf/ en_US
dash.license LAA
dc.subject neuroscience en_US
dc.subject behavioral neuroscience en_US
dc.subject cognitive neuroscience en_US
dc.subject neurodevelopment en_US
dc.subject mental health en_US
dc.subject dementia en_US
dc.subject developmental and pediatric neurology en_US
dc.title Temporal Lobe Cortical Electrical Stimulation during the Encoding and Retrieval Phase Reduces False Memories en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Fregni, Felipe
dc.date.available 2011-06-13T14:20:49Z
dash.affiliation.other HMS^Neurology- Beth Israel-Deaconess en_US
dash.affiliation.other HMS^Neurology- Beth Israel-Deaconess en_US

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