Browsing FAS Theses and Dissertations by Author "Wakeley, John"
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Estimating TMRCA, Modeling the Fixed Pedigree, and the Effect of the Y Chromosome on the Chromatin Landscape
King, Leandra (2016-09-06)This thesis consists of three chapters on different topics. Chapter 1: We demonstrate the advantages of using information at many unlinked loci in order to better calibrate estimates of the time to the most recent common ... -
Frontiers in Coalescent Theory: Pedigrees, Identity-by-Descent, and Sequentially Markov Coalescent Models
Wilton, Peter R. (2016-05-14)The coalescent is a stochastic process that describes the genetic ancestry ofindividuals sampled from a population. It is one of the main tools of theoretical population genetics and has been used as the basis of many ... -
Genomic variation and evolution of the human malaria parasite Plasmodium falciparum
Chang, Hsiao-Han (2013-10-08)Malaria is a deadly disease that causes nearly one million deaths each year. Understanding the demographic history of the malaria parasite Plasmodium falciparum and the genetic basis of its adaptations to antimalarial ...