Browsing FAS Theses and Dissertations by Title
Now showing items 2129-2148 of 6136
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Exploiting the Regulation of Apoptosis to Improve Therapeutic Responses of Tumors to mTOR Inhibitors
(2023-01-09)The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is constitutively activated in most human cancers and in the genetic tumor syndrome tuberous sclerosis complex (TSC). Due to its role in driving anabolic processes ... -
An Exploration of the Function of Lamps in Archaic and Classical Greek Culture: Use, Concepts, and Symbolism
(2013-02-13)Scholarship on Archaic and Classical Greek lamps has traditionally been in the form of typological studies and catalogues. This dissertation represents an alternative to such works, offering a fuller picture of the function ... -
Explorations in cancer genomics and tumor immunology through analysis of next-generation sequencing data
(2022-03-17)Cancer is an evolutionary disease. From the time we are a fertilized egg, our cells are subject to processes that can alter DNA sequence and epigenetics leading to random changes in cell fitness. Certain phenotypes can ... -
Explorations in de Sitter Space and Amorphous Black Hole Bound States in String Theory
(2013-09-30)This dissertation is split into two distinct halves. The first covers various calculations done in order gain insights on holography in de Sitter space. The dispersion relation of linear perturbations of empty de Sitter ... -
Exploring Biomolecular Interactions Through Single-Molecule Force Spectroscopy and Computational Simulation
(2016-04-11)Molecular interactions between cellular components such as proteins and nucleic acids govern the fundamental processes of living systems. Technological advancements in the past decade have allowed the characterization of ... -
Exploring Black Hole Dynamics
(2014-11-20)This thesis explores the evolution of different types of black holes, and the ways in which black hole dynamics can be used to answer questions about other physical systems. We first investigate the differences in ... -
Exploring Bystander Selection for Antibiotic Resistance
(2021-03-05)Antibiotic consumption exerts selection for antibiotic resistance. Due to the wide spectrum of activity of many antibiotics, a single antibiotic use may impose selective pressures on a range of bacterial species, including ... -
Exploring Cancer's Fractured Genomic Landscape: Searching for Cancer Drivers and Vulnerabilities in Somatic Copy Number Alterations
(2014-10-21)Somatic copy number alterations (SCNAs) are a class of alterations that lead to deviations from diploidy in developing and established tumors. A feature that distinguishes SCNAs from other alterations is their genomic ... -
Exploring Correlations of High Altitude Aerosol Formation in Planetary Systems with Similar Parameters
(2023-05-11)High altitude aerosols prevent our ability to probe exoplanet atmospheres, by muting or completely obscuring molecular and atomic features. Unfortunately, the vast majority of planets are obscured by high altitude aerosols, ... -
Exploring Dengue Virus Entry through Small Molecule Inhibition and Mutagenesis of the Envelope Protein
(2013-03-15)Over one-third of the world’s population is at risk for infection with dengue virus (DENV), a mosquito-borne virus that can cause a severe febrile disease. There are no specific treatments available for dengue infection, ... -
Exploring exact dualities in lattice models of topological phases of matter
(2022-05-12)Dualities are central to our understanding of physics, in particular in the study of quantum phases of matter. In this dissertation, we explore exact lattice dualities that relate various topological phases of matter, which ... -
Exploring Implicit Voice Theories at Work
(2013-02-20)In modern organizations, individuals frequently choose silence over voice (e.g., Milliken, Morrison, & Hewlin, 2003), which can have a variety of detrimental effects on individuals and organizations. This choice of silence ... -
Exploring Intra-tumor Cooperation in Metastasis and Drug Resistance using Heterogeneous Xenograft Models of Breast Cancer
(2016-05-03)Breast cancer is a highly heterogeneous disease, having not only several intrinsic sub-types but also significant sub-clonal heterogeneity within tumors. Intra-tumor heterogeneity can have profound impact on tumor evolution, ... -
Exploring Mobile Screen Media Use Among Preschoolers and the Implications for Supporting Children’s Early Language and Literacy Skills
(2022-01-18)Technology has become an integral part of everyday life. Mobile media devices, in particular, are now an essential component of mainstream lifestyle, whereby adults rely on mobile devices not only to communicate, but also ... -
Exploring Models for Implementing Differential Privacy
(2022-09-08)Researchers across many fields use statistical analysis on collected data to make decisions and inform policy. However, datasets collected from individuals may contain sensitive information. Ideally, we want to perform ... -
Exploring Objective Causal Inference in Case-Noncase Studies under the Rubin Causal Model
(2015-05-15)Case-noncase studies, also known as case-control studies, are ubiquitous in epidemiology, where a common goal is to estimate the effect of an exposure on an outcome of interest. In many areas of application, such as ... -
Exploring Pre- and Postmenopausal Breast Cancer Risk Factors through Metabolomics and Risk Prediction Modeling
(2021-11-16)Evidence suggests that breast cancer, long recognized as a hormonal disease, also has a metabolic component influencing its development. However, etiologic mechanisms of breast cancer, including those related to metabolism, ... -
Exploring Radiation’s Effects on Lung Cancer, with a focus on Motility and Migration
(2022-06-03)Lung cancer is one of the deadliest forms of cancer. A common therapeutic agent is radiation, but there is beginning to be more and more evidence about how radiation can actually have effects on motility and migration, ... -
Exploring Single-Cell Chromatin Organization with Multiplexed DNA-FISH: Towards an Imaging Platform for Single-Cell Multi-Omics
(2021-01-06)The three-dimensional (3D) organization of chromatin in the nucleus has been an active area of research for many years. Chromatin organization during interphase has especially drawn much attention over the past two decades ... -
Exploring Strategies to Promote a Healthier Food Environment
(2022-05-12)Excess weight, which affects over 70% of the population in the United States, has been associated with a plethora of chronic diseases, including diabetes, cardiovascular disease, some cancers, and mortality. As posited by ...