Browsing FAS Theses and Dissertations by Title
Now showing items 2348-2367 of 6136
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From the Job’s Worth to the Person’s Price: Pay-Setting, Gender Inequality, and the Changing Understanding of Fair Pay
(2022-06-06)How do employers set pay for job candidates? The idea that job candidates are paid their “market price” is now widely institutionalized but beliefs about the right way to set pay have varied over time. This dissertation ... -
From the S-matrix to the lattice: bootstrapping QFTs
(2023-05-11)In this thesis, I present our attempts to formulate new bootstrap approaches to Quantum Field Theories. The main goal of these approaches is to offer complementary techniques to the Effective Field Theory paradigm. Namely, ... -
From Urban Form to Friending Bias: Testing Jane Jacobs’ Hypotheses
(2023-06-30)Recent work has shown that social integration can influence a variety of outcomes ranging from educational attainment to overall health to income inequality. This paper examines the extent to which urban design can foster ... -
From Wilderness to the Toxic Environment: Health in American Environmental Politics, 1945-Present
(2013-09-30)This dissertation joins the history of science and medicine with environmental history to explore the language of health in environmental politics. Today, in government policy briefs and mission statements of environmental ... -
From Womb to Doom: Mechanical Regulation of Cardiac Tissue Assembly in Morphogenesis and Pathogenesis
(2013-02-14)The assembly, form, and function of the heart is regulated by complex mechanical signals originating from intrinsic and extrinsic sources, such as the cytoskeleton and the extracellular matrix. During development, mechanical ... -
Frontiers in Coalescent Theory: Pedigrees, Identity-by-Descent, and Sequentially Markov Coalescent Models
(2016-05-14)The coalescent is a stochastic process that describes the genetic ancestry ofindividuals sampled from a population. It is one of the main tools of theoretical population genetics and has been used as the basis of many ... -
Fueling Galaxy Growth Through Gas Accretion in Cosmological Simulations
(2015-05-17)Despite significant advances in the numerical modeling of galaxy formation and evolution, it is clear that a satisfactory theoretical picture of how galaxies acquire their baryons across cosmic time remains elusive. In ... -
Full-sky, High-resolution Maps of Interstellar Dust
(2015-05-12)We present full-sky, high-resolution maps of interstellar dust based on data from the Wide-field Infrared Survey Explorer (WISE) and Planck missions. We describe our custom processing of the entire WISE 12 micron All-Sky ... -
Fully Homomorphic Encryption with Applications to Privacy-Preserving Machine Learning
(2023-06-30)There are two dominant trends today that appear to be mutually exclusive: on the one hand, machine learning services that provide accurate predictions based on personal data have become widespread, but on the other hand, ... -
Fully Synthetic Trioxacarcins for Use in Antibody-Drug Conjugates
(2021-05-10)Dissertation advisor: Professor Andrew G. Myers Ethan L. Magno Fully Synthetic Trioxacarcins for Use in Antibody-Drug Conjugates Abstract Antibody-drug conjugates (ADCs) have emerged as an effective, targeted therapeutic ... -
Function and inhibition of the lipopolysaccharide floppase MsbA
(2021-11-16)MsbA is an ATP-binding Cassette (ABC) transporter tasked with flipping lipopolysaccharide (LPS) across the inner membrane of Gram-negative bacteria. Interrupting LPS transport by blocking MsbA leads to cell death, making ... -
Function and mechanism of the gasdermin family
(2021-09-07)Inflammasomes are signaling structures of the innate immune system that activate caspase-1 and other inflammatory caspases (caspase-4 and -5 in humans and -11 in mice) in response to pathological challenges and endogenous, ... -
The function of the Heg-CCM pathway in zebrafish heart development
(2013-10-08)The Heart of glass-Cerebral Cavernous Malformation (Heg-CCM) pathway is essential for heart development in zebrafish and mouse. In zebrafish, mutants for the Heg-CCM genes ccm1, ccm2, and heg exhibit an extreme dilation ... -
Function-on-Function Regression with Public Health Applications
(2014-06-06)Medical research currently involves the collection of large and complex data. One such type of data is functional data where the unit of measurement is a curve measured over a grid. Functional data comes in a variety of ... -
Function-Specific Serotonergic Neurons in the Control of Breathing and Body Temperature
(2015-10-05)The control of respiration and body temperature involves neural circuits within the brainstem modulated by the neurotransmitter serotonin (5HT), though it is unclear precisely which serotonergic neurons are critical to ... -
Functional analysis of Miro GTPase domains in the mitochondrial motor adaptor complex
(2020-12-18)Mitochondria are actively transported in all somatic cells where their motility is essential for proper cellular function. Mitochondrial transport relies on microtubules and a highly regulated motor/adaptor complex that ... -
Functional analysis of multiple activities associated with the herpes simplex virus-1 DNA polymerase
(2018-05-11)Of the DNA replication proteins required for herpes simplex virus-1 (HSV-1) viral replication, the catalytic subunit of the DNA polymerase (Pol) has been the most extensively studied, both as a model for Family B polymerases ... -
Functional Analysis of Notch Signaling during Vertebrate Retinal Development
(2013-02-25)The process of cell fate determination, which establishes the vastly diverse set of neural cell types found in the central nervous system, remains poorly understood. During retinal development, multipotent retinal progenitor ... -
Functional and Genomic Analyses of Klebsiella Pneumoniae Population Dynamics in the Gastrointestinal Tract
(2015-12-17)The gastrointestinal tract is home to trillions of bacteria that interact with each other and with the host’s mucosal immune system. Obligate and facultative anaerobes thrive in the small and large intestine. While many ... -
Functional and genomic analysis of MEF2 transcription factors in neural development
(2014-10-21)Development of the central nervous system requires the precise coordination of intrinsic genetic programs to instruct cell fate, synaptic connectivity and function. The MEF2 family of transcription factors (TFs) plays many ...