Browsing FAS Theses and Dissertations by Issue Date
Now showing items 21-40 of 6136
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Mediated, mitigated, liberated: Hélio Oiticica’s participatory art and the reinvention of the public
(2024-03-12)This dissertation studies the complex and contentious relationship between Brazilian artist Hélio Oiticica (1937-1980) and his public. This relationship is important because Oiticica was one of the first proponents of ... -
Nanofabrication platforms for metasurface optics: From prototyping to mass-production
(2024-03-12)Manipulating light using sub-wavelength scale structures (meta-atoms), once a purely theoretical concept for shorter electromagnetic wavelengths, has become achievable thanks to advances in high-end semiconductor manufacturing ... -
Algorithms for Political Methodology in the Information Age
(2024-03-12)Contemporary politics is bound to an unprecedented volume of online information, and to the algorithms and social networks that deliver it. From millions of online campaign ads to billions of fake news social media posts, ... -
Exponentially Faster Submodular Maximization in Practice via Low Adaptivity Algorithms
(2024-03-12)Across machine learning, social network analysis, and algorithms, many fundamental objectives we care to optimize are submodular, such as influence, innovation diffusion, clustering, mutual information, feature selection, ... -
Ethics Amidst Uncertainty: Essays on Global Health Priority Setting
(2024-03-12)Global health actors must allocate limited resources. For instance, non-governmental organizations must decide which public health interventions to prioritize, research funders must decide what grants to make, and governments ... -
Unveiling the Molecular Architecture of Mammalian Ciliary Doublet Microtubules and Mechanisms of von Willebrand Factor Concatemerization
(2024-03-12)Cilia are molecular appendages of cells that accomplish tasks requiring stunning coordination. Remarkable examples in humans include motile cilia in the respiratory tract that utilize motility to escalate allergens and ... -
Political Ecologies and the Transformation of Landscape in the Early Modern Delaware Valley
(2024-03-12)This dissertation uses the concept of political ecology to explore the nature of colonization and the subsequent landscape transformation in the early modern Delaware Valley. The question of how European colonization changed ... -
Multi-omics interrogation of metabolic stress in cancer
(2024-03-12)Cancer is associated with alterations to many pathways and cellular processes, including activation of pro-growth cell signaling pathways, resistance to cell death, activation of metastasis, and evasion of the immune system. ... -
New Functional Assays Reveal Previously Unrecognized Roles for Nucleotide Excision Repair in Genome Maintenance and Immune Activity
(2024-03-12)Nucleotide excision repair is well-studied as a critical factor in genome maintenance, protecting the cell from external mutagens presenting on the DNA in the form of bulky adducts. The delicate balance of this pathway ... -
The Local Consequences of Migration Policies in Latin America, Africa, and North America
(2024-03-12)Global migration is on the rise. Around the world, towns and cities and community members grapple with the consequences of migration -- there are responses of solidarity and permissive policies as well as flares of xenophobia ... -
Chromatin Regulation of Transcriptional Repression in the Developing Brain
(2024-03-12)The complex organization of the brain is enabled by the precise coordination of developmental and activity-dependent gene programs. Mechanisms acting at the level of chromatin play a key role in promoting, repressing, or ... -
Gene expression programs in the nose
(2024-03-12)Sensory processing in the nose filters the external olfactory world and supports a wide variety of olfactory behaviors that are fundamental to life. Natural odor stimuli are complex mixtures of volatile chemicals that ... -
Defining the crosstalk between the transcription and splicing machineries
(2024-03-12)Production of mammalian messenger RNAs (mRNAs) often requires RNA Polymerase II (RNAPII) to transcribe tens of kilobases and coordinate the co-transcriptional removal of multiple introns by the spliceosome. The expansion ... -
X-inactivation mosaicism and the effects of X-linked mutations in the human brain
(2024-03-12)Cells in every human female have inactivated one or the other X chromosome (X1 or X2). To enable analysis of this epigenetic mosaicism – and its biological effects – we developed a computational approach that uses single-cell ... -
The Politics of Karameh: Palestinian Dignity and Defiance Against the Necrocarceral State
(2024-03-12)For decades, Israel has systematically confiscated and withheld the bodies of slain Palestinians as a form of punishment and control over the living. The bodies are deposited without proper identification in secret ... -
A New Solidarity: Race, Diversity, and the Development of Modern Harvard, 1869-1969
(2024-03-12)Few would associate America’s university modernizers, serving between the Civil War and World War II, with present-day attempts to make universities more diverse and inclusive. They were, however, in many ways, pioneers ... -
Demonic (Dis)Possessions: Indigenous Gold from the Colombia-Panama Borderlands
(2024-03-12)This dissertation takes a long view at the marginalization in archaeological models of pre-Conquest metallurgy from northern Chocó and Urabá in the Colombia-Panama borderlands. It was here, where Europeans found—in the ... -
Health Care Variation and Its Determinants: Studies on Physician Quality, Cancer Screening, and Cardiovascular Care
(2024-03-12)This dissertation investigates drivers of variation in health care utilization and quality, with a focus on physician decision-making and patient outcomes. The first chapter examines the distribution of new physician quality ... -
Recapitulating and Understanding Human Embryonic Axial Elongation and Neurulation
(2024-03-12)Embryonic development is a complex interplay between intercellular signaling, intracellular gene expression dynamics, and multicellular rearrangements. How cells in the embryo choose their fates and structure themselves ... -
Eating Behaviors in Adolescence and Young Adulthood and Adult Cardiometabolic Disease Risk
(2024-03-12)Cardiometabolic diseases, including type 2 diabetes (T2D), hypertension, and high cholesterol, are significant public health concerns. Understanding risk factors and mechanisms of disease progression can shape prevention ...