Browsing FAS Theses and Dissertations by Title
Now showing items 1527-1546 of 6136
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Energy Allocation to Adolescent Skeletal Growth: Impacts of Insulin and Physical Activity
(2021-05-14)Life history theory dictates that organisms should precisely allocate investment of their limited resources, including energy, to a variety of tasks to serve natural selection’s ultimate goal: reproduction. In adolescence, ... -
Energy Allocation to Skeletal Muscle After Physical Activity: The Role of Interleukin-6
(2023-09-08)Interleukin-6 (IL-6) is a multifunctional cytokine with disparate and often contradictory effects. A superficial explanation for this functional diversity is that IL-6 is highly context-dependent and performs a different ... -
Engaging Chiral Cationic Intermediates by Anion-Binding in Asymmetric Catalysis
(2016-01-13)Anion-binding catalysis by dual hydrogen-bond donors such as ureas and squaramides has been demonstrated as a powerful strategy for the development of highly enantioselective transformations involving prochiral cationic ... -
Engineered Biofilms for Materials Production and Patterning
(2016-04-22)Natural materials, such as bone, integrate living cells composed of organic molecules together with inorganic components. This enables combinations of functionalities, such as mechanical strength and the ability to regenerate ... -
Engineered Collisions, Molecular Qubits, and Laser Cooling of Asymmetric Top Molecules
(2023-05-16)In this dissertation, I present studies of molecules for uses in quantum science ranging from quantum computing and ultracold collisions to controlling organic-inspired molecular species. Starting with a diatomic molecule, ... -
Engineered Curli-Expressing Biofilms as a Platform for Biocatalysis
(2015-12-14)Research and innovation in recent years has led to a paradigm shift in the bioengineering community regarding biofilms. Rather than focusing on their negative impact in disease and materials fouling, we, and other groups, ... -
Engineered DNA-Binding Proteins for Targeted Genome Editing and Gene Regulation
(2013-10-08)Engineered DNA-binding proteins enable targeted manipulation of the genome. Zinc fingers are the most well characterized DNA-binding domain and for many years research has focused on understanding and manipulating the ... -
Engineered Materials for Improving Cancer Immunotherapy
(2017-01-11)Immunotherapy, the treatment of disease through targeted activation of the immune system, has recently shown unprecedented clinical success for diverse malignancies. In contrast to traditional cancer treatments, which are ... -
Engineered potentials and dynamics of ultracold quantum gases under the microscope
(2014-06-06)In this thesis, I present experiments on making and probing strongly correlated gases of ultracold atoms in an optical lattice with engineered potentials and dynamics. The quantum gas microscope first developed in our lab ... -
Engineered proteins that enable site-specific protein and genome modification
(2021-11-16)Dissertation Advisor: David R. Liu Christopher John Podracky Engineered proteins that enable site-specific protein and genome modification Abstract Protein engineering, whether by rational design or ... -
Engineering a Biomimetic Adventitia to Model Fibrosis in a Tissue-Engineered Blood Vessel
(2023-06-30)Cardiovascular disease (CVD) is the global leading cause of death. CVD is commonly caused by fibrosis, or the stiffening of arterial vessel walls. While arterial fibrosis has several pathophysiologies, the outermost vessel ... -
Engineering a Functionalized Biofilm-Based Material for Modulating Escherichia Coli’s Effects in the Mammalian Gastrointestinal Tract
(2015-06-26)This study investigates the potential use of engineered bacterial biofilms as programmable platforms to control bacterial-epithelial interactions in the mammalian gut. It is clear that commensal microflora play a critical ... -
Engineering a proximity-directed O-GlcNAc transferase to control O-GlcNAc signaling
(2021-11-16)O-GlcNAc is a ubiquitous monosaccharide posttranslational modification analogous to phosphorylation found on thousands of nuclear and cytoplasmic proteins involved in every major cellular process. Dysregulation of O-GlcNAc ... -
Engineering and evolution of precision genome editing agents
(2022-06-06)Genome editing agents have had a transformative effect on the study of biological systems, the engineering of cells and organisms with novel properties, and even the treatment of genetic diseases in the clinic. This ... -
Engineering Bacteria for Bio-Based Chemicals Production and Gut Microbiota Applications
(2018-09-16)Microbes have been used for production of food and beverages for thousands of years. In the last century we have begun to modify them by means of genetic engineering to produce more complex compounds and we have gained ... -
Engineering Cardiac Valve Extracellular Matrix Structure and Function for Modeling Pathogenesis and Regeneration
(2017-01-03)Fibrosis of the semilunar cardiac valves clinically manifests as deterioration in late-stage functional performance. Stenotic insufficiencies, due to either congenital or acquired heart valve disease, are a result of ... -
Engineering cooperativity for the control of biomolecular self-assembly
(2023-06-01)How does the complexity of biology reliably emerge from the interactions of individual molecules? This dissertation takes a deeper look at one of the mechanisms involved in ensuring the robustness of biomolecular self-assembly ... -
Engineering CRISPR-Based DNA Transversion Editing Technologies
(2022-01-11)Adenine base editors (ABE) and cytosine base editors (CBE) can efficiently install A-to-G and C-to-T transition edits, respectively. However, until recently, the field lacked base editors to efficiently install C-to-G ... -
Engineering E. coli Nissle 1917 to advance and facilitate its use in biomedical applications
(2021-05-06)The concept of engineered living therapeutics refers to the utilization and reprogramming of living cells for a wide range of medical applications. Currently, most examples focus on engineering microbes for use in the human ... -
Engineering Escherichia Coli Fatty Acid Metabolism for the Production of Biofuel Precursors
(2015-05-07)Medium chain fatty acids (MCFAs, 6-12 carbons) are potential precursors to biofuels with properties similar to gasoline and diesel fuel but are not native products of Escherichia coli fatty acid synthesis. Herein we engineer ...