Browsing FAS Theses and Dissertations by Title
Now showing items 2150-2169 of 6136
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Exploring the composition and mineralogy of the mantle with stable isotopes and machine learning
(2023-06-01)Since its origin more than 4.5 billion years ago, the Earth has undergone a dynamic evolution driven by the slow cooling of its interior. Two-way mass exchange between its interior (i.e., the mantle) and exterior reservoirs ... -
Exploring the development and diversification of the unique Aquilegia nectar spur
(2022-05-09)Angiosperms are the most species-rich and morphologically diverse group in the plant kingdom, yet are also the most recently evolved. The flower itself, unique to the angiosperms, is where much of this diversity is on ... -
Exploring The Early Navajo Pastoral Landscape: An Archaeological Study of (Peri)Colonial Navajo Pastoralism from the 18th to 21st Centuries AD
(2022-01-11)How did Indigenous communities negotiate the introduction of new animal species and associated economic practices in colonial contexts? Attempts to answer this question in the American Southwest have focused largely on the ... -
Exploring the effect of interactions on multicellular spatial structures, stability of gene expression and microbial evolution
(2021-03-05)There are many ways that cells in a colony can interact with one another. For example, metabolic cross-feeding often occurs in bacterial communities where some cells secrete diffusible metabolites that are taken up and ... -
Exploring the Features and Challenges of Proteolysis Targeting Chimera (PROTAC) Development
(2023-01-20)Small molecule inhibitors offer a powerful approach to modulate biological systems, having been successfully used as probes to interrogate protein functions and as drug therapies. However, many proteins of therapeutic ... -
Exploring the genetic landscape of complex diseases using the recessive model
(2014-06-06)High-throughput sequencing technologies have changed the way we identify, study and understand the role of rare variation in Mendelian diseases. Sequencing in complex diseases have proven to be more challenging to interpret, ... -
Exploring the Impact of Human and Pathogen Behavior on Infectious Disease Dynamics
(2023-06-01)The COVID-19 pandemic has spurred recognition of the many ways humans interact to influence infectious disease dynamics. The success of non-pharmaceutical interventions revealed the importance of contact rates between ... -
Exploring the Impact of Unilateral Affirmative Action on the School Choice Problem
(2023-06-30)Affirmative action in school choice has become a burgeoning area of interest for policymakers and researchers alike. Numerous efforts have sought to characterize the impact of affirmative action on common matching mechanisms ... -
Exploring the Implications of Extended-Release HIV Therapeutics on Disease Outcome and Risk of Drug Resistance
(2016-07-06)While many HIV therapies are now available, greatly improving disease prognosis for patients, long-term adherence to treatment regimens remains a serious problem. Recent advances in drug delivery have made possible new ... -
Exploring the Limits of Geophysical Models of Solar Geoengineering
(2022-05-13)Solar Radiation Modification (SRM) is a proposed method of reducing climate risks associated with climate change via modification of Earth's radiative budget. Due to the impracticality of global experimentation, research ... -
Exploring the Long-Term and Extreme Variability of Stars
(2012-08-23)This thesis presents observational studies of long-term and extreme variability of stars with the Digital Access to a Sky Century@Harvard (DASCH) project. Stellar variations over decades are poorly explored. With the unique ... -
Exploring the nature of early social preferences: The case of music
(2012-08-06)This dissertation aims to explore the nature of early social preferences by testing attention to a cue that might have evolved as a reliable signal of shared group membership – shared cultural knowledge. Part 1 shows that ... -
Exploring the Plasticity of Cellular Fate Using Defined-Factor Reprogramming
(2012-11-02)Cellular fate, once established, is usually stable for the lifetime of the cell. However, the mechanisms that restrict the developmental potential of differentiated cells are in principle reversible, as demonstrated by the ... -
Exploring the Reaction Space of a Tricobalt Nitride
(2017-05-12)Reaction chemistry was explored from the tricobalt platform [(tbsL)Co3] where [tbsL]6– = [1,3,5-C6H9(NC6H4-o-NSitBuMe2)3]6–. Treatment of the polynucleating ligand tbsLH6 with three equivalents of metalating agent ... -
Exploring the role of microRNAs in airway smooth muscle biology and asthma therapy
(2014-06-06)The pathophysiology of asthma is characterized by airway inflammation, remodeling and hyper-responsiveness. Phenotypic changes in airway smooth muscle cells (ASM) play a pivotal role in the pathogenesis of asthma. ASM cells ... -
Exploring the Role of Randomization in Causal Inference
(2015-05-11)This manuscript includes three topics in causal inference, all of which are under the randomization inference framework (Neyman, 1923; Fisher, 1935a; Rubin, 1978). This manuscript contains three self-contained chapters. Chapter ... -
Exploring the therapeutic potential of cell state specific binders to the β-barrel assembly machine
(2022-06-06)Gram-negative bacterial infections are particularly difficult to treat as the presence of the outer membrane (OM) makes them intrinsically resistant to many antibiotics used in the clinic. Understanding how the impermeable OM ... -
Exploring the Use of Human Pluripotent Stem Cells to Create Functional Pancreatic \(\beta\) Cells
(2013-03-18)Directed differentiation of human pluripotent stem cells (hPSCs) has the potential to produce human cell types that can be used for disease modeling and cell transplantation. Two key challenges in the differentiation from ... -
Exploring the Wide Net of Human Energy Systems: From Carbon Dioxide Emissions in China to Hydraulic Fracturing Chemicals Usage in the United States
(2017-08-24)Human energy systems have profound and far-reaching impacts, from global to regional levels. This thesis examines two seemingly distinct issues that are intrinsically united by the growing human appetite for energy and ... -
Exponentially Faster Submodular Maximization in Practice via Low Adaptivity Algorithms
(2024-03-12)Across machine learning, social network analysis, and algorithms, many fundamental objectives we care to optimize are submodular, such as influence, innovation diffusion, clustering, mutual information, feature selection, ...