Browsing FAS Theses and Dissertations by Keyword "KDM1A"
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Illuminating the nonenzymatic functions of LSD1 complexes in leukemia using drug resistance alleles
(2023-01-10)The identification of drug resistance conferring mutations not only confirms on-target small molecule mechanism but can also serve as a useful discovery tool to uncover novel aspects of target biology. However, the ... -
New Mechanisms of Activation by Histone Demethylases in Gene Regulation
(2013-10-15)The epigenetic mechanisms that connect hormone signaling to chromatin remain largely unknown. Here we show that LSD1/KDM1A is a critical glucocorticoid receptor (GR) coactivator and report a previously unexplored mechanism ...