Browsing FAS Theses and Dissertations by Keyword "vaccines"
Now showing items 1-5 of 5
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Clonal Analysis of Mucosal SIV-Specific CD8+ T Cell Responses
(2013-02-26)CD8+ T cells responses are critical in the immune defense against human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection. A major challenge for vaccine development is that HIV/SIV can rapidly ... -
MFG-E8 Blockade Enhances Tumor Immunity in a Murine Breast Cancer Model
(2013-03-08)Milk fat globule - epidermal growth factor - factor 8 protein (MFG-E8) is an important mediator of the tolerogenic functions of GM-CSF, and a dominant-negative RGE mutant augments the therapeutic potential of irradiated, ... -
Quantitative Approaches Towards Evaluating the Global Burden of Mental Illness
(2023-06-01)Mental disorders are a leading cause of morbidity and mortality, affecting over one billion people worldwide. This burden, across all levels of socioeconomic development, is rising, yet the majority of people living with ... -
Vaccine responses in the context of impaired self-tolerance
(2021-07-12)In the context of HIV vaccine design, broadly-neutralizing antibodies (bnAbs) are those which are able to neutralize a diverse population of HIV variants. The existing global diversity of HIV necessitates that any traditional ... -
Vaccines: Populations, Individuals and Models
(2023-06-01)The 2009 H1N1 influenza and 2019 SARS-CoV-2 pandemics have highlighted the need for control measures against emerging infectious diseases. Vaccines are currently the most effective intervention against these pathogens, ...