Browsing FAS Theses and Dissertations by Title
Now showing items 1-20 of 3632
-
1,2-Selective Hydrosilylation of Conjugated Dienes
(2014-06-06)Selective 1,2-hydrosilylation of 1,3-dienes is a challenging problem to solve for transition metal catalysis. Butadiene, specifically, would be a useful substrate because 3-butenylsilane products have promise as superior ... -
The 1824 Confederation of the Equator and Cultural Production in Brazil
(2015-05-17)During the 1824 Confederation of the Equator revolt in northeastern Brazil, a middle-class junta rose to power and waged a war against the monarchy in Rio, journalists participating in creating pedagogical ideological ... -
2-Selmer groups and Heegner points on elliptic curves
(2015-05-07)This thesis studies several aspects of the arithmetic of elliptic curves. In particular, we explore the prediction of the Birch and Swinnerton-Dyer conjecture when the 2-Selmer group has rank one. For certain elliptic ... -
3D Bioprinting of Vascularized Human Tissues
(2016-04-26)The ability to manufacture human tissues that replicate the spatial, mechano-chemical, and temporal aspects of biological tissues would enable myriad applications, including drug screening, disease modeling, and tissue ... -
4d Spectra from BPS Quiver Dualities
(2013-09-26)We attack the question of BPS occupancy in a wide class of 4d N = 2 quantum field theories. We first review the Seiberg-Witten approach to finding the low energy Wilsonian effective action actions of such theories. In ... -
A Capitalizing City: Dar Es Salaam and the Emergence of an African Entrepreneurial Elite (C. 1862-2015)
(2018-09-19)A Capitalizing City charts the ways some people of African descent in Dar es Salaam, the commercial and industrial capital of Tanzania, have attempted, historically, to either integrate into the modern capitalist system ... -
A Clock-Phased Sigma Factor Cascade Is Required for Global Circadian Transcriptional Rhythms in Cyanobacteria
(2017-09-07)The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 drives oscillations in global mRNA transcript abundances with 24 h periodicity under continuous light conditions. The transcription factor RpaA ... -
A Computational Approach to Analysis and Control\\of the Mammalian Circadian Oscillator
(2018-05-11)Circadian rhythms, endogenous, entrainable, near-24 h oscillations in metabolism, are a nearly ubiquitous feature of life on Earth. Circadian rhythms function as a feedforward biological control system that reorganizes ... -
A Discriminative Model to Predict Comorbidities in ASD
(2016-06-21)Children with autism spectrum disorders face a higher comorbidity burden than the general pediatric population. Machine learning applications have been applied to structured medical data, specifically electronic health ... -
A Floating Probe Force Microscope With Sub-Femtonewton Resolution
(2017-01-13)Forces at the femtonewton level and below are poised to be highly relevant in a number of scientific disciplines– including studies in optics and photonics, molecular biology, and even microfluidics. It is highly practical, ... -
A Formalization of Elements of Special Relativity in Coq
(2017-07-14)We present a formalization of elements of special relativity in Coq beginning from a set of first-order axioms, towards demonstrating that Coq may be used to formalize physical reasoning at the level of introductory physics. ... -
A Framework for Protein-Level Interpretation of Genetic Associations and Integration With Large-Scale DNA Sequencing Analysis
(2017-05-10)With recent rapid decrease in exome and genome sequencing price amount of the available sequencing data has dramatically increased. While analysis of common genetic variation has succeeded with GWAS and fine-mapping ... -
A Framework for Understanding Small Nervous Systems
(2017-01-09)How do we find important neurons and understand how their dynamics control behavior? Both of these are challenging and general problems in neuroscience. In this dissertation supervised by Sharad Ramanathan, I developed a ... -
A general strategy to construct small molecule biosensors
(2017-05-10)Biosensors for small molecules can be used in applications that range from metabolic engineering to orthogonal control of transcription. Despite their broad utility, it remains a longstanding challenge to rapidly create ... -
A Global View of Translation in Vesicular Stomatitis Virus Infected Cells
(2018-01-19)Infection of mammalian cells with vesicular stomatitis virus (VSV) results in the inhibition of cellular translation, while viral translation proceeds efficiently. This host “shutoff” is mediated by multiple mechanisms. ... -
A Grand Journey of Statistical Hierarchical Modelling
(2017-05-03)This thesis presents three research reports composed by the candidate and his collaborators on different perspectives and applications of statistical hierarchical modelling, which seeks to connect the observed quantities ... -
A Graphical Theory of Musical Pitch Spelling
(2018-06-29)Based on the conventions of staff-based music notation, musical passages that sound alike can often be written down in multiple ways, with each representation being considered a different "pitch-spelling". In this thesis, ... -
A Living Extracorporeal Device for Proximal Tubule Reabsorption
(2017-07-14)Currently, 700,000 patients suffer from end-stage renal disease (ESRD) with treatment costs over $42B in the US, yet the 5-year survival of patients on dialysis is only 35% while that of full-organ transplantation is over ... -
A Markov Approach to Modeling Baseball At-Bats and Evaluating Pitcher Decision-Making and Performance
(2016-06-21)The author models baseball at-bats using absorbing Markov chains, formed based on pitch-by-pitch data for 90 pitchers from the 2015 season. These matrices are used to reverse-predict performance statistics that compare ... -
A method for identifying predictive markers of mental illness in social media data
(2017-02-14)Undiagnosed mental illness poses a significant health risk. In-person screenings to identify individuals at-risk of mental illness are expensive, time-consuming, and often inaccurate. This report presents an array of ...