Browsing FAS Theses and Dissertations by Title
Now showing items 1-20 of 4139
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1,2-Selective Hydrosilylation of Conjugated Dienes
(2014-06-06)Selective 1,2-hydrosilylation of 1,3-dienes is a challenging problem to solve for transition metal catalysis. Butadiene, specifically, would be a useful substrate because 3-butenylsilane products have promise as superior ... -
The 1824 Confederation of the Equator and Cultural Production in Brazil
(2015-05-17)During the 1824 Confederation of the Equator revolt in northeastern Brazil, a middle-class junta rose to power and waged a war against the monarchy in Rio, journalists participating in creating pedagogical ideological ... -
2-Selmer groups and Heegner points on elliptic curves
(2015-05-07)This thesis studies several aspects of the arithmetic of elliptic curves. In particular, we explore the prediction of the Birch and Swinnerton-Dyer conjecture when the 2-Selmer group has rank one. For certain elliptic ... -
3D Bioprinting of Vascularized Human Tissues
(2016-04-26)The ability to manufacture human tissues that replicate the spatial, mechano-chemical, and temporal aspects of biological tissues would enable myriad applications, including drug screening, disease modeling, and tissue ... -
4d Spectra from BPS Quiver Dualities
(2013-09-26)We attack the question of BPS occupancy in a wide class of 4d N = 2 quantum field theories. We first review the Seiberg-Witten approach to finding the low energy Wilsonian effective action actions of such theories. In ... -
“‘A Bath of Continuous Sensations’: Warren Brodey’s Quest for Human Augmentation and Intelligent Environments, 1955-1975”
(2018-05-13)This dissertation traces the professional and intellectual development of Warren Brodey (b. 1924). Trained as a psychiatrist and psychoanalyst, Brodey was one of the pioneers of family therapy but eventually abandoned his ... -
A Capitalizing City: Dar Es Salaam and the Emergence of an African Entrepreneurial Elite (C. 1862-2015)
(2018-09-19)A Capitalizing City charts the ways some people of African descent in Dar es Salaam, the commercial and industrial capital of Tanzania, have attempted, historically, to either integrate into the modern capitalist system ... -
A Chemical Biology Platform to Develop Small Molecule Probes for Bromodomains
(2017-05-16)Bromodomain epigenetic reader proteins play crucial roles in the pathogenesis of diseases ranging from inflammation to cancer. Small molecule inihibitors have engendered a nuanced understanding of the role of BET subfamily ... -
A Clock-Phased Sigma Factor Cascade Is Required for Global Circadian Transcriptional Rhythms in Cyanobacteria
(2017-09-07)The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 drives oscillations in global mRNA transcript abundances with 24 h periodicity under continuous light conditions. The transcription factor RpaA ... -
A Computational Approach to Analysis and Control\\of the Mammalian Circadian Oscillator
(2018-05-11)Circadian rhythms, endogenous, entrainable, near-24 h oscillations in metabolism, are a nearly ubiquitous feature of life on Earth. Circadian rhythms function as a feedforward biological control system that reorganizes ... -
A Constellation of Outposts: French Intelligence Services and the Administration of the French Protectorate of Morocco, 1912-1937
(2018-09-25)This dissertation examines the metastasis of the French colonial intelligence state. It argues that rogue intelligence officers hijacked power in the French Protectorate of Morocco and created a covert regime to evade ... -
A Discriminative Model to Predict Comorbidities in ASD
(2016-06-21)Children with autism spectrum disorders face a higher comorbidity burden than the general pediatric population. Machine learning applications have been applied to structured medical data, specifically electronic health ... -
A Floating Probe Force Microscope With Sub-Femtonewton Resolution
(2017-01-13)Forces at the femtonewton level and below are poised to be highly relevant in a number of scientific disciplines– including studies in optics and photonics, molecular biology, and even microfluidics. It is highly practical, ... -
A Formalization of Elements of Special Relativity in Coq
(2017-07-14)We present a formalization of elements of special relativity in Coq beginning from a set of first-order axioms, towards demonstrating that Coq may be used to formalize physical reasoning at the level of introductory physics. ... -
A Framework for Protein-Level Interpretation of Genetic Associations and Integration With Large-Scale DNA Sequencing Analysis
(2017-05-10)With recent rapid decrease in exome and genome sequencing price amount of the available sequencing data has dramatically increased. While analysis of common genetic variation has succeeded with GWAS and fine-mapping ... -
A Framework for Understanding Small Nervous Systems
(2017-01-09)How do we find important neurons and understand how their dynamics control behavior? Both of these are challenging and general problems in neuroscience. In this dissertation supervised by Sharad Ramanathan, I developed a ... -
A general strategy to construct small molecule biosensors
(2017-05-10)Biosensors for small molecules can be used in applications that range from metabolic engineering to orthogonal control of transcription. Despite their broad utility, it remains a longstanding challenge to rapidly create ... -
A Genome-Wide Knock-Out Screen Identifies Novel Host Cell Entry Factor Requirements for Divergent Adeno-Associated Virus Serotypes
(2019-01-16)Adeno-Associated Virus (AAV) is a non-pathogenic virus that has been harnessed as a vector system for therapeutic gene transfer. Despite decades of research on AAV as a vector, little is known about the molecular determinants ... -
A Global View of Translation in Vesicular Stomatitis Virus Infected Cells
(2018-01-19)Infection of mammalian cells with vesicular stomatitis virus (VSV) results in the inhibition of cellular translation, while viral translation proceeds efficiently. This host “shutoff” is mediated by multiple mechanisms. ... -
A Grand Journey of Statistical Hierarchical Modelling
(2017-05-03)This thesis presents three research reports composed by the candidate and his collaborators on different perspectives and applications of statistical hierarchical modelling, which seeks to connect the observed quantities ...