Browsing FAS Theses and Dissertations by Keyword "kinase inhibitor"
Now showing items 1-2 of 2
-
Leveraging diverse data modalities to study kinase inhibitor polypharmacology
(2021-11-16)Kinases constitute a popular class of drug targets and to date over 60 kinase inhibitors have been approved for clinical use by the U.S. Food and Drug Administration (FDA). Despite the clinical efficacy of these inhibitors, ... -
Signaling and Feedback Networks Underlying Senstivity and Resistance to Kinase Inhibitors in Oncogene Addicted Cancers
(2013-01-02)Targeted therapies have begun to be developed and approved in the clinic over the past several decades to treat cancers with specific genetic alterations. In non-small cell lung cancer (NSCLC), patients harboring EGFR ...