Browsing FAS Theses and Dissertations by Keyword "ubiquitin"
Now showing items 1-2 of 2
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Defining the Ubiquitin and E2-Enzyme Requirements for APC/C-Mediated Degradation of Cyclin B1
(2012-09-12)Post-translational modification of proteins with ubiquitin regulates many aspects of cell physiology, including protein degradation. A uniform polyubiquitin chain that is linked through Lys48 has been widely accepted as ... -
Mass Spectrometry-Based Proteomics Approaches to Define Enzyme-Substrate Relationships in the Ubiquitin Proteasome System
(2022-11-23)The ubiquitin proteasome system (UPS) is a major regulator of cellular protein abundance, degrading proteins that are tagged with a ubiquitin post-translational modification. Respectively, E3 ubiquitin ligases and ...