Now showing items 1-10 of 23
Study on Bacterial Protein Synthesis System toward the Incorporation of D-Amino Acid & Synthesis of 2'-deoxy-3'-mercapto-tRNA
Life is anti-entropic and highly organized phenomenon with two characteristics reinforcing each other: homochirality and the stereospecific catalysis of chemical reactions. The exclusive presence of L-amino acids and ...
Directed Evolution of Sortase Activity and Specificity
Nature employs complex networks of protein-tailoring enzymes to effect the post-translational modification of proteins in vivo. By comparison, modern chemical methods rely upon either nonspecific labeling techniques or ...
Discovery of bioactive lipids and lipid pathways in cell death and disease
Apoptosis is an intricately regulated cellular process required for the health and homeostasis of living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro- and anti-apoptotic members whose ...
Progress Toward the Total Synthesis of the Lomaiviticins and a Biomimetic Unified Strategy for the Synthesis of 7-Membered Ring-Containing Lycopodium Alkaloids
Lomaiviticin A (1) and B (2) are natural products with remarkably complex C2-symmetric structures and potent antiproliferative properties. Achieving total syntheses of 1 and 2 has been a long-standing project in the Shair ...
Oxidative Assembly of the Outer Membrane Lipopolysaccharide Translocon LptD/E and Progress towards Its X-Ray Crystal Structure
Lipopolysaccharide (LPS) is the glycolipid that comprises the outer leaflet of the Gram-negative outer membrane (OM). Because it is essential in nearly all Gram-negative species, and because it is responsible for making ...
Earth-abundant water-splitting catalysts coupled to silicon solar cells for solar-to-fuels conversion
Direct solar-to-fuels conversion can be achieved by coupling semiconductors with water-splitting catalysts. A 10% or higher solar to fuels conversion is minimally necessary for the realization of a robust future technology. ...
Trapping and Manipulating Single Molecules of DNA
This thesis presents the development and application of nanoscale techniques to trap and
I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides
Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two ...
Design and synthesis of dynamically assembling DNA nanostructures
Kinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed ...
Progress Toward the Total Synthesis of Vinigrol and Hibarimicin B
Vinigrol is a structurally unique diterpenoid natural product featuring a tricyclo[188.8.131.52.4a,8a]tetradecene carbon skeleton containing eight contiguous stereocenters and a challenging oxygenation pattern. Vinigrol has ...