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Mechanisms Governing Mesothelial Clearance by Ovarian Cancer Spheroids
(2013-10-08)
Metastatic dissemination of ovarian tumors involves the invasion of multi-cellular tumor cell clusters into the mesothelial cell lining of organs in the peritoneal cavity. We developed an in vitro assay that models this ...
Linking Metabolic Rates with the Diversity and Functional Capacity of Endolithic Microbial Communities within Hydrothermal Vent Structures
(2013-10-18)
At hydrothermal vents, thermal and chemical gradients generated by the mixing of hydrothermal fluids with seawater provide diverse niches for prokaryotic communities. To date, our knowledge of environmental factors that ...
Structure and development of Rafflesiaceae
(2013-10-17)
Rafflesiaceae produce the largest flowers among all flowering plants, measuring up to a meter in diameter and weighting 7 kg, and have been a source of amazement since their discovery about two centuries ago. In addition ...
Molecular Dissection of Neural Circuits Underlying Parental Behavior in Mice
(2013-10-18)
Mice display robust and stereotyped behaviors towards pups: virgin males typically attack pups, while virgin females and sexually experienced males display parental care. I show here that virgin males that are genetically ...
Evolution of Bivalvia: Multi-level phylogenetic and phylogenomic reconstructions within Bivalvia (Mollusca) with emphasis on resolving familial relationships within Archiheterodonta (Bivalvia: Heterodonta).
(2013-10-15)
With an estimated 8,000-20,000 species, bivalves represent the second largest living class of molluscs (Bieler et al. 2013). Revived interest in molluscan phylogeny has resulted in a torrent of molecular sequence data from ...
Single-cell Sequencing Studies of Somatic Mutation in the Human Brain
(2013-10-08)
A major unanswered question in neuroscience is whether there exists genomic variability between individual neurons of the brain, contributing to functional diversity or to an unexplained burden of neurologic disease. To ...
Genomic Tools Reveal Changing Plasmodium falciparum Populations
(2013-09-25)
A new era of malaria eradication programs relies on increased knowledge of the parasite through sequencing of the Plasmodium genome. Programs call for re-orientation at specific epidemiological markers as regions move from ...
Characterization of Malaria Sexual Stage Development in the Human Host
(2013-09-26)
Due to an increase in malaria control programs in the last decade, the world has witnessed dramatic reductions in the number of infections and deaths caused by the malaria parasite. With malaria eradication on the global ...
Sensational Propellers: Novel Protein Functions in Cilia Assembly and Motility
(2013-09-18)
Cilia and flagella are hair-like projections found on the surface of virtually every vertebrate cell. These microtubule-based organelles are historically known for their striking motility, a valuable tool for the manipulation ...
Mechanical and Thermal Food Processing Effects on Mastication and Cranio-Dental Morphology
(2013-09-30)
Chimpanzees spend ~40% of their day chewing fruits, seeds, and tough leaves and pith, while in contrast modern humans spend significantly less time eating (5%), and the foods that they consume are extremely soft and ...