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Loss of Insulin Receptor Substrates 1 and 2 Suppresses Kras-Driven Non-Small Cell Lung Cancer
(2017-07-06)
Lung cancer remains the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) being the majority of diagnosed cases of lung cancer. Mutant KRAS is found in about 25% of all NSCLC and has proved ...
In Vivo Genetic Screening to Identify Mechanisms of Resistance to Cancer Immunotherapy
(2017-10-10)
Despite the dramatic clinical success of cancer immunotherapy with PD-1 checkpoint blockade, most patients do not experience sustained clinical benefit from treatment, suggesting that additional therapeutic strategies are ...
Molecular Determinants and Transcriptional Regulators in Triple Negative Breast Cancer
(2015-08-07)
Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast
tumors are classified based on the ...
Evolving Models of Ovarian Cancer: Defining the Role of PAX8 in Fallopian Tube Tumorigenesis
(2015-08-07)
Ovarian cancer is the most deadly gynecological malignancy in the US. Once thought to be a single disease arising from the ovarian surface epithelium, we now understand that it is in fact a heterogenous disease with origins ...
A Structural and Functional Investigation of Germ Plasm Organization Mediated by D. Melanogaster Oskar Protein
(2015-09-25)
Germ cells are the unique source of gametes for multicellular organisms and are specified through different mechanisms. One such specification mechanism is inheritance-mediated, in which the molecular factors necessary and ...
Genome-Wide RNAi Screens for Novel Regulators of Acute Myeloid Leukemia
(2015-01-15)
Acute myeloid leukemia (AML) is a heterogeneous disease with complex molecular mechanisms. Recent advent of genomic technologies, such as copy number profiling, whole genome sequencing, and gene expression profiling has ...
The Role of Sorting Nexin 10 (Snx10) in Control of Osteoclast Function and Regulation of Bone Homeostasis
(2014-11-20)
Sorting Nexin 10 (Snx10) is expressed in osteoclasts and is required for osteoclastic bone resorption in vitro. To study the role of Snx10 in osteoclastic bone resorption and bone homeostasis in vivo, we investigated the ...
Structural Studies of a Subunit of the Murine Cytomegalovirus Nuclear Egress Complex
(2015-01-20)
The Herpesviridae family of viruses includes a number of human pathogens of clinical importance. Like other herpesviruses, cytomegaloviruses require a heterodimeric nuclear egress complex (NEC) consisting of a membrane-bound ...
Mesendoderm Patterning by the Nodal/Lefty Activator/Inhibitor System
(2015-01-16)
During zebrafish embryogenesis, a gradient of the secreted TGFβ ligand Nodal induces expression of mesendodermal genes in an exposure-dependent manner, and also induces expression of the secreted Nodal feedback inhibitor ...
Mechanisms of Stem Cell Maintenance and Cell Differentiation in the Intestinal Epithelium
(2015-01-23)
Constant regeneration of the intestinal epithelium, a dynamic tissue with vital digestive and barrier functions, depends on proliferation of resident stem cells and their differentiation into mature cell types. This ...