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The Regulation of Immunological Processes by Peripheral Neurons
(2015-09-23)
The nervous system and the immune system are the primary sensory interfaces between the internal and external environment. They are responsible for recognizing, integrating, and responding to stimuli with the appropriate ...
Biology of Type 2 Phosphatidylinositol-5-Phosphate 4-Kinase
(2015-09-22)
Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three genes, PIP4K2A, PIP4K2B and PIP4K2C that encode the enzymes ...
The Regulatory T Cell Response to Skeletal Muscle Injury and Its Decline With Age
(2015-08-07)
Efficient skeletal muscle regeneration requires the accumulation of Foxp3+CD4+ regulatory T (Treg) cells. Muscle Tregs have a transcriptome and T cell receptor repertoire distinct from Tregs found in other tissues. The ...
Diverse Approaches to Developing Combination Therapies for NF1-Mutant Cancers
(2015-05-13)
The NF1 tumor suppressor is lost or mutated in a variety of sporadic cancers, as well as in the hereditary cancer predisposition syndrome neurofibromatosis type 1 (NF1). NF1 patients have an 8–13% risk of developing a ...
A Zebrafish Model of Uveal Melanoma
(2015-05-06)
Uveal melanoma is the most common primary intraocular tumor in adults, and is often characterized by poor prognosis and few effective therapeutic options. The typical site of metastasis for uveal melanoma is the liver, and ...
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Secondary Hyperlipidemias
(2016-05-16)
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) has emerged over the past decade as an important regulator of plasma cholesterol and cardiovascular disease risk. PCSK9 promotes degradation of low density lipoprotein ...
Strategies for Studying Chromatin Regulation and Organization
(2016-04-22)
The epigenetic regulation of gene transcription underlies the diversity between species and within organisms. Novel implementation of existing methods and the development of original technologies continue to contribute ...
Molecular Patterns and Signatures of Longevity
(2016-05-02)
Since their divergence from a common ancestor some 200 million years ago, mammals have undergone significant diversification in physiology, morphology, habitat, size, and longevity. The maximum lifespan of mammalian species ...
Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation
(2016-05-09)
The gastrointestinal (GI) epithelium is a highly regenerative tissue with the potential to provide a renewable source of insulin+ cells using cellular reprogramming. Here, I describe the antral stomach as a previously ...
Oncogenic Control and Metabolic Outputs of the Lipogenic Transcription Factor SREBP
(2016-05-11)
The sterol regulatory element binding protein (SREBP) transcription factors have emerged as central regulators of de novo lipogenesis in the liver. However, while it is known that lipid synthesis is elevated in many cancers, ...