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The Roles of RNA-binding Proteins in the Developing Nervous System
(2014-02-25)
RNA-binding proteins are key players in post-transcriptional regulation of gene expression by orchestrating RNA fate from synthesis to decay. Hundreds of proteins with RNA-binding capacity have been identified so far, yet ...
Phosphatome RNAi Screen Identifies Eya1 as a Positive Regulator of Hedgehog Signal Transduction
(2013-10-18)
The Hedgehog (Hh) signaling pathway is vital for vertebrate embryogenesis and aberrant activation of the pathway can cause tumorigenesis in humans. In this study, we used a phosphatome RNAi screen for regulators of Hh ...
Directed differentiation of mouse embryonic stem cells into neocortical output neurons
(2013-10-18)
During development of the neocortex, many diverse projection neuron subtypes are generated under regulation of cell-extrinsic and cell-intrinsic controls. One broad projection neuron class, corticofugal projection neurons ...
The role of Ppargc1álpha in neuronal survival and myelination in the neocortex
(2014-02-25)
The mammalian neocortex contains diverse neuronal and glial cell types. Among them lies an important subclass, the subcerebral projection neurons (SCPN) that project to distant targets like the spinal cord. Aiming at ...
Innate Immune Molecules Direct Microglia-Mediated Developmental Synaptic Refinement
(2014-06-06)
Microglia, the brain's resident immune cells and phagocytes, are emerging as critical regulators of developing synaptic circuits in the healthy brain after having long been thought to function primarily during central ...
ZNF335: A Novel Regulator of Stem Cell Proliferation and Cell Fate in the Cerebral Cortex
(2013-03-18)
Though development of the cerebral cortex is of singular importance to human cognition, it remains very poorly understood. Microcephaly, or "small head," is a neurodevelopmental disorder causing significantly reduced ...
Transcriptional Controls over Neocortical Projection Neuron Identity and Connectivity
(2013-03-18)
The complex and sophisticated circuitry of the neocortex is assembled from an extraordinarily diverse repertoire of neuronal subtypes that reside in distinct functional areas. In recent years, a number of key regulators ...
Molecular Controls over Developmental Acquisition of Diverse Callosal Projection Neuron Subtype Identities
(2013-03-18)
The mammalian neocortex is an exquisite, highly organized brain structure composed of hundreds of subpopulations of neurons and glia, precisely connected to enable motor control, sensory perception, information integration, ...
DEVELOPMENT AND FUNCTIONS OF C-LOW-THRESHOLD MECHANORECEPTORS
(2013-10-08)
Somatosensory neurons are essential for detecting diverse environmental stimuli, thus critical for survival of mammals. In order to achieve sensory modality specificity, many somatosensory subtypes emerge with various ...
The role of Netrin-1 in semicircular canal morphogenesis
(2014-11-12)
The vestibular system of the inner ear detects head position using three orthogonally oriented semicircular canals. Vestibular function relies on precise canal shape and orientation, and slight changes can cause vestibular ...