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The Use of Oncology Electronic Health Record Databases to Assess the Effectiveness of Breast Cancer Treatment
(2022-01-14)
Background: Non-experimental studies using large healthcare databases may be well-suited for addressing relevant questions in clinical oncology that pertain to the safety and effectiveness of medications. They complement ...
Quantum nonlinear optics: controlling few-photon interactions
(2021-03-05)
Most phenomena around us can be explained by classical optics since photons interact weakly with atoms. When the interaction is strong enough where one photon affects the properties of other photons, we go to the regime ...
Laboratory and Modeling Studies of the Sources and Sinks of Oxygenated Volatile Organic Compounds in Forests
(2022-12-22)
The biosphere acts as a significant source and sink of reactive organic carbon that can regulate atmospheric composition via formation of pollutants such as tropospheric ozone (O3) and secondary organic aerosol (SOA). Both ...
Examining Mental Health in Black Communities Using Intersectional Approaches
(2021-07-12)
Few epidemiologic studies have disaggregated U.S. Black populations when exploring the impacts of racism, at multiple levels, on mental health. Intersectionality theory, as developed by Black feminist organizers and scholars, ...
Novel computational frameworks for driver gene identification and evolutionary informed genomics analysis in melanoma and prostate cancer
(2022-01-20)
We performed harmonized molecular and clinical analysis on 1,048 melanoma whole-exomes and discovered markedly different global genomic properties among genomic subtypes (BRAF, (N)RAS, NF1, Triple Wild-Type), subtype-specific ...
Design and Characterization of Hybrid Biological-Inorganic Systems
(2023-03-14)
Hybrid biological-inorganic systems have been designed to drive fine chemical syntheses and to interrogate fundamental biology. These systems couple electronic signals to cellular activity, allowing the unique chemistries ...
Quality Control of Translation Factors
(2022-12-22)
Protein synthesis is a remarkably error prone process, necessitating protein quality control pathways to recognize and resolve these abnormal events.
In chapters 2 and 3, I examine downstream steps in the ribosome-associated ...
The Relationship Between Herpes Simplex Virus 1 and the Cellular DNA Damage Response
(2021-01-19)
Cellular DNA is under constant threat from many different agents that can cause damage to the genome. Damage to the DNA can inhibit the ability of the cell to replicate its genome, which usually leads to death of the cell. ...
The Bad Faith Argument in Ancient Jewish Thought
(2021-11-16)
Though much scholarly attention has been devoted to the relations between Jews and gentiles in antiquity, surprisingly little literature has investigated how Jews constructed and portrayed the religion of gentile pagans. ...
Integration of common and rare genetic variation across complex traits and neuropsychiatric disorders
(2022-09-08)
Research into the genetic basis of human disease has progressed rapidly over the past 20 years. Genome-wide association studies have identified thousands of links between common variants and phenotypic outcomes. More ...