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Small-Molecule Modulators of Pancreatic Ductal Cells: Histone Methyltransferases and \(\beta\)-Cell Transdifferentiation
(2013-03-06)
Small molecules are important not only for treating human diseases but also for studying disease-related biological processes. This dissertation focuses on the effects of small molecules on pancreatic ductal adenocarcinoma ...
I. Completion of a Total Synthesis of Peloruside A. II. Studies toward the Total Synthesis of Spiro-Prorocentrimine
(2013-03-05)
I. Completion of a Total Synthesis of Peloruside A: The completion of a 22 step synthesis of the marine natural product peloruside A is presented. The second generation strategy cuts 10 steps from longest linear sequence ...
C-H Amination Catalysis from High-Spin Ferrous Complexes
(2013-10-15)
The C-H amination and olefin aziridination chemistry of iron supported by dipyrromethene ligands (RLAr, L=1,9-R2-5-aryldipyrromethene, R = Mes, 2,4,6-Ph3C6H2, tBu, Ad, 10-camphoryl, Ar = Mes, 2,4,6-Cl3C6H2) was explored. ...
Dynamic Hybrid Materials: Hydrogel Actuators and Catalytic Microsystems
(2013-09-30)
Dynamic materials which can sense changes in their surroundings and subsequently respond or adapt by autonomously altering their functionality, surface chemistry, transparency, color, wetting behavior, adhesiveness, shape, ...
A Systematic Experimental and Computational Approach to Investigating Phosphotyrosine Signaling Networks
(2013-09-24)
Mutation and over-expression of Receptor Tyrosine Kinases (RTKs) or the proteins they regulate serve as oncogenic drivers in diverse cancers. RTKs catalyze the transfer of phosphate from ATP to the hydroxyl group on tyrosine. ...
Dissecting the Mechanisms of Direct Activation for Proapoptotic BAK and BAX
(2013-10-08)
Dissecting the Mechanisms of Direct Activation for Proapoptotic BAK and BAX
Total Synthesis of Aflastatin A
(2013-08-21)
The syntheses of aflastatin A and its C3-C48 degradation fragment are described. The syntheses feature several complex diastereoselective fragment couplings, including a C35-C36 anti-Felkin-selective boron-mediated oxygenated ...
I. Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis II. Development of a Practical Method for the Synthesis of Highly Enantioenriched Trans-1,2-Amino Alcohols
(2013-08-21)
A highly enantioselective acylation of silyl ketene acetals with acyl fluorides was developed to generate useful α,α-disubstituted butyrolactone products in high yield and excellent enantioselectivities. This transformation ...
Late First-Row Transition Metals in Weak Ligand Fields - Correlating High-Spin Electronic Structure and Reactivity
(2013-09-16)
High spin has been shown to be necessary for optimal reactivity of transition metal complexes toward the activation and functionalization of C-H bonds. This thesis presents our examination of the weak-field, tripodal, ...
The Role of Interstitials and Surface Defects on Oxidation and Reduction Reactions on Titania
(2013-07-25)
This thesis focuses on understanding the influence of defect sites in titanium dioxide that drive many types of thermal and photochemical reactions. Two of the most common defects in vacuum are titanium interstitials and ...