Search
Now showing items 1-10 of 216
Late-Stage Fluorination with \(^{18}F\)
(2013-03-19)
Positron emission tomography (PET) is a powerful, non-invasive in vivo imaging technique used for diagnostics and drug development. The synthesis of \(^{18}F\)-PET tracers is challenging due to the short half-life of the ...
Multifunctional Three-Dimensional Nanoelectronic Networks for Smart Materials and Cyborg Tissues
(2015-09-28)
Nanomaterials provide unique opportunities at the interface between nanoelectronics and biology. “Bottom-up” synthesized nanowire(NW) with defined functionality can be assembled and enabled into three-dimensional(3D) ...
Activation of Electron-Deficient Quinones Through Hydrogen-Bond-Donor-Coupled Electron Transfer
(2015-09-23)
Quinones are organic oxidants that play important roles in biological contexts and find wide application in organic synthesis. They are known to be activated toward electron transfer through hydrogen bonding, which has ...
A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil From [18F]Fluoride for Human PET Imaging
(2015-07-20)
5-Fluorouracil is a broad-spectrum chemotherapeutic for cancer treatment. [18F]5-Fluorouracil, which contains the radioactive isotope fluorine-18, is a tracer for positron emission tomography (PET) imaging and has been ...
The Discovery and Characterization of Endosomal Escape Enhancing Compounds to Improve Protein Delivery Efficacy
(2015-07-23)
The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. We and others have previously shown that superpositively charged proteins are ...
Study on Bacterial Protein Synthesis System toward the Incorporation of D-Amino Acid & Synthesis of 2'-deoxy-3'-mercapto-tRNA
(2014-06-06)
Life is anti-entropic and highly organized phenomenon with two characteristics reinforcing each other: homochirality and the stereospecific catalysis of chemical reactions. The exclusive presence of L-amino acids and ...
Directed Evolution of Sortase Activity and Specificity
(2014-06-06)
Nature employs complex networks of protein-tailoring enzymes to effect the post-translational modification of proteins in vivo. By comparison, modern chemical methods rely upon either nonspecific labeling techniques or ...
Discovery of bioactive lipids and lipid pathways in cell death and disease
(2014-06-06)
Apoptosis is an intricately regulated cellular process required for the health and homeostasis of living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro- and anti-apoptotic members whose ...
Progress Toward the Total Synthesis of the Lomaiviticins and a Biomimetic Unified Strategy for the Synthesis of 7-Membered Ring-Containing Lycopodium Alkaloids
(2014-10-21)
Lomaiviticin A (1) and B (2) are natural products with remarkably complex C2-symmetric structures and potent antiproliferative properties. Achieving total syntheses of 1 and 2 has been a long-standing project in the Shair ...
Oxidative Assembly of the Outer Membrane Lipopolysaccharide Translocon LptD/E and Progress towards Its X-Ray Crystal Structure
(2014-10-21)
Lipopolysaccharide (LPS) is the glycolipid that comprises the outer leaflet of the Gram-negative outer membrane (OM). Because it is essential in nearly all Gram-negative species, and because it is responsible for making ...