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Studies towards a Solution Structure of the Peptidoglycan Glycosyltransferases
(2012-09-13)
Peptidoglycan glycosyltransferases (PGTs) are highly conserved bacterial enzymes that catalyze the polymerization of the lipidic disaccharide, Lipid II, to form individual peptidoglycan (PG) strands which are subsequently ...
Label-Free Optical Imaging of Chromophores and Genome Analysis at the Single Cell Level
(2012-11-01)
Since the emergence of biology as a quantitative science in the past century, a lot of biological discoveries have been driven by milestone technical advances such as X-ray crystallography, fluorescence microscopy and ...
Silver-Mediated Trifluoromethoxylation of Aryl Nucleophiles and Synthesis of 3-Deoxy-3-Fluoromorphine
(2012-11-14)
Fluorine incorporation has become increasingly important in pharmaceutical applications. Upon fluorination and incorporation of fluorinated moieties such as trifluoromethoxy groups, many small molecules become more ...
Synthesis of Cortistatin Alkaloids and a Versatile Synthesis of Isoquinolines
(2012-08-10)
The cortistatins are a recently identified class of marine natural products that were found to exhibit potent and selective inhibition of human umbilical vein endothelial cells (HUVECs), making them promising leads for the ...
Pseudoephenamine: A Practical Chiral Auixiliary for Asymmetric Synthesis
(2013-02-25)
Pseudoephedrine has been used as a chiral auxiliary in diastereoselective alkylation reactions, providing easy access to enantiomerically enriched carboxylic acids, alcohols, ketones, and aldehydes. Because pseudoephedrine ...
Metabolomics Strategies for Discovery of Biologically Active or Novel Metabolites
(2013-02-08)
Along with genes and proteins, metabolites play important roles in sustaining life. There remains much to be learned about the in vivo roles of metabolites. Metabolomics is a comparative tool to study global metabolite ...
Studies on Application of Silyl Groups in Ring-Closing Metathesis Reactions and Fragment-Based Probe Discovery
(2012-12-19)
In efforts to search for tool compounds that are capable of probing normal and disease-associated biological processes, both quality and identity of the screening collection are very important. Towards this goal, ...
Using Live Cell Imaging to Probe Biogenesis of the Gram-Negative Cell Envelope
(2013-02-08)
In Gram-negative bacteria, the three-layered cell envelope, including the cell wall, outer and inner membranes, is essential for cell survival in the changing, and often hostile environments. Conserved in all prokaryotes, ...
Nanowires as Optoelectronic and Photonic Elements
(2013-02-08)
Integrated photonic circuits require small photonic elements. Recent progress in nanowire synthesis and nanofabrication enables us to investigate the potential of nanowires in novel integrated photonic devices. This thesis ...
Development and Deployment of Optical Instruments to Measure Trace Atmospheric Species: I. Water Isotopologues; II. Glyoxal; III. Iodine Monoxide
(2012-12-13)
Understanding future climate requires observations of trace species that can significantly influence the chemical or radiative properties of the atmosphere. The development of optical instruments, utilizing laser-systems ...