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Transcriptional and Epigenetic Dynamics Observed During Lineage Specification of Human Embryonic Stem Cells
(2014-02-25)
Epigenetic regulation of gene expression is essential for faithful cellular specification during embryonic development. Directed differentiation of pluripotent human embryonic stem cells (hESCs), which maintain the ability ...
Investigating Cytoskeletal Motor Mechanisms using DNA Nanotechnology
(2014-02-25)
The microtubule cytoskeleton plays a vital role in the spatial-temporal organization of subcellular cargo required to maintain homeostasis and direct cell division. Cytoplasmic dynein and kinesin are opposite-polarity, ...
Central role for Sonic hedgehog-triggered pericytes in hindbrain choroid plexus development
(2014-02-25)
The choroid plexus is an organ within each brain ventricle comprised of elaborate folds of epithelium (CPe) and vasculature. It performs numerous functions essential for brain development and health, including secretion ...
The Role of Dendritic Cell Subsets in Cross-presentation and Stimulation of Homing Marker Expression
(2014-02-25)
Topical antigen (Ag) application mimics natural Ag exposure across the skin. Soluble Ag introduced through this route requires cross-presentation by dendritic cells (DCs) to generate CD8 T cell responses, including skin-homing ...
Low Speed Avian Maneuvering Flight
(2014-02-25)
Low speed avian maneuvering flight is an ecologically crucial behavior that has contributed to the explosive diversification of several avian taxa by allowing access to complex spatial environments. Negotiating a sharp ...
Long non-coding RNAs interact with PRC1 to impact Polycomb group protein recruitment and expression of Polycomb regulated genes
(2014-02-25)
Long non-coding RNAs (lncRNAs) are increasingly recognized as important regulators of genomic processes and cellular specification. Many lncRNAs regulate chromatin by functionally impacting the epigenetic state through ...
Functional organization of the circadian timing system
(2014-02-25)
The circadian timing system establishes daily rhythms in behavior and physiology throughout the body, ensuring that functions like activity, sleep and hormone release are appropriately timed. Research suggests that his ...
Cutaneous Biology and Endogenous Opioids: How the Skin Modulates Pain and Addiction
(2014-02-25)
The Proopiomelanocortin gene, (POMC), produces many biologically active peptides including the endogenous opioid, β-endorphin, and the melanocortins: α-Melanocyte Stimulating Hormone, (αMSH), γMSH, ...
TNF gene expression in macrophage activation and endotoxin tolerance
(2014-02-25)
TNF is an inflammatory cytokine that plays a critical role in the acute phase response to infection, and its dysregulation has been implicated in the pathology of several inflammatory and autoimmune disorders. TNF gene ...
Airway Dynamics and the Role of Zyxin
(2014-06-06)
Morbidity and mortality attributable to asthma arise mainly from contraction of airway smooth muscle (ASM) and resulting bronchospasm. Bronchospasm that is induced in the laboratory is easily reversed by a spontaneous deep ...