At the start of the 20th century, communicable diseases accounted for the majority of deaths in the United States. Advances in public health over the course of the century greatly reduced the impact of these diseases and ...

Whole-body regeneration relies on the re-establishment of body axes for correct patterning of tissue outgrowth. Wnt signaling is utilized to correctly regenerate tissues along the primary axis in many animals, including ...

Biology uses strategic, coordinated proximity events to orchestrate complex cellular pathways essential to homeostasis, survival, and propagation. The interrogation of biological systems with chemogenomic approaches has ...

During development, it is crucial that gene expression patterns, which define cell phenotypes and “epigenetic states”, are stably inherited. The maintenance of epigenetic states involves changes in repressive histone ...

Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these ...

The problem of predicting a protein's 3D structure from its primary amino acid sequence is a longstanding challenge in structural biology. Recently, approaches like AlphaFold have achieved remarkable performance on this ...

Three-dimensional structure has been used as a starting point to characterize protein function since the advent of X-ray crystallography in the 1950s. However, not all proteins bear stable tertiary or even secondary ...

Obesity is a complex metabolic disorder that poses significant challenges to public health and individual wellbeing. While diet and exercise serve as valuable first line treatments for obesity, additional approaches are ...

The metabolism of a proliferative cell must meet biosynthetic demand by breaking down multiple nutrients to produce energy and the building blocks of cell growth. Many of the core metabolic reactions of the cell require ...

Genome editing agents have had a transformative effect on the study of biological systems, the engineering of cells and organisms with novel properties, and even the treatment of genetic diseases in the clinic. This ...