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Improving metabolic health via dietary and pharmacologic modulation of stress response pathways
(2020-11-23)
At the start of the 20th century, communicable diseases accounted for the majority of deaths in the United States. Advances in public health over the course of the century greatly reduced the impact of these diseases and ...
Heads or Tails? Regulation of Wnt signaling and axial identity establishment during whole-body regeneration in the acoel worm Hofstenia miamia
(2020-10-06)
Whole-body regeneration relies on the re-establishment of body axes for correct patterning of tissue outgrowth. Wnt signaling is utilized to correctly regenerate tissues along the primary axis in many animals, including ...
Development of CoraFluors: A Versatile, Target-agnostic Assay Technology Platform Optimized for Chemical Biology Research
(2022-11-23)
Biology uses strategic, coordinated proximity events to orchestrate complex cellular pathways essential to homeostasis, survival, and propagation. The interrogation of biological systems with chemogenomic approaches has ...
Locus-Dependent Epigenetic Inheritance of Polycomb-Mediated Gene Silencing
(2022-05-10)
During development, it is crucial that gene expression patterns, which define cell phenotypes and “epigenetic states”, are stably inherited. The maintenance of epigenetic states involves changes in repressive histone ...
Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms
(2022-05-10)
Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these ...
Evidence for and Applications of Physics-Based Reasoning in AlphaFold
(2022-05-23)
The problem of predicting a protein's 3D structure from its primary amino acid sequence is a longstanding challenge in structural biology. Recently, approaches like AlphaFold have achieved remarkable performance on this ...
Disordered proteins regulate stress- & damage-dependent DNA binding
(2023-01-18)
Three-dimensional structure has been used as a starting point to characterize protein function since the advent of X-ray crystallography in the 1950s. However, not all proteins bear stable tertiary or even secondary ...
Preadipocyte IL-13-IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARɣ activity
(2023-03-14)
Obesity is a complex metabolic disorder that poses significant challenges to public health and individual wellbeing. While diet and exercise serve as valuable first line treatments for obesity, additional approaches are ...
Regulatory Mechanisms Linking Coenzyme A Synthesis and PI3K Signaling
(2023-03-14)
The metabolism of a proliferative cell must meet biosynthetic demand by breaking down multiple nutrients to produce energy and the building blocks of cell growth. Many of the core metabolic reactions of the cell require ...
Engineering and evolution of precision genome editing agents
(2022-06-06)
Genome editing agents have had a transformative effect on the study of biological systems, the engineering of cells and organisms with novel properties, and even the treatment of genetic diseases in the clinic. This ...