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Transposable Elements in Health and Disease
(2021-11-16)
Transposable elements are DNA sequences that can move within the genome. They play a pivotal role in genomic variability in humans and can cause diseases. Their repetitive nature requires specific computational algorithms ...
Mesoscopic physiological interactions in the human brain reveal small-world properties and associations with behavior
(2021-04-29)
Cognition depends on rapid and robust communication between neural circuits spanning different brain areas. Here we investigated the mesoscopic network of cortico-cortical interactions in the human brain in an extensive ...
Markov Chain Monte Carlo Sampling Algorithms in Neural Circuitry
(2022-06-03)
There is growing evidence that the nervous system is tuned and adapted to the sta- tistical properties of the sensory information from the surrounding environment and that it is possible that the brain performs some form ...
Substantia nigral activity in self-timed movements
(2023-01-09)
The basal ganglia (BG) are a set of subcortical nuclei involved in movement and other aspects of behavioral control. Diseases of the basal ganglia cause difficulty in the initiation and execution of movements. The main ...
Functional analysis of Miro GTPase domains in the mitochondrial motor adaptor complex
(2020-12-18)
Mitochondria are actively transported in all somatic cells where their motility is essential for proper cellular function. Mitochondrial transport relies on microtubules and a highly regulated motor/adaptor complex that ...
Optical investigation of microcircuit computations in mouse primary visual cortex
(2022-01-20)
A fundamental challenge of visual cortical neuroscience is to understand how sensory representations are transformed within and across layers of primary visual cortex (V1). Visual signals are thought to propagate in a ...
Diverse physiology and function of dopaminergic neurons in behaving Drosophila
(2021-05-14)
In many animals, including both mammals and insects like Drosophila, dopamine is associated with learning, motivation, and regulation of voluntary movement. In mammals, the activity of individual dopaminergic neurons (DANs) ...
Olfactory Evidence Accumulation in Mice
(2021-07-12)
In nature, odor cues from distant objects are sparse and highly fluctuating due to turbulent airflow. Animals may integrate odor concentration sampled over time rather than rely on transient odor concentration to effectively ...
Ultrastructural insights into mammalian cutaneous mechanoreceptors
(2021-05-07)
Cutaneous mechanoreceptors are a morphologically and functionally diverse class of primary sensory neurons in mammals that transduce mechanical stimuli acting on the skin into electrical impulses. These neurons reside in ...
Dopamine in the tail of striatum regulates post-assessment avoidance of stimulus novelty
(2021-11-16)
Novelty drives animals’ active sampling of their environment and influences learning. Novel objects evoke characteristic behavioral responses such as approach, retreat, and avoidance of these objects, but how the complex ...