Search
Now showing items 1-10 of 32
Dynamic regulation of histone lysine methylation via the ubiquitin-proteasome system.
(2013-10-18)
Lysine methylation is an important post-translational modification found on histones that is added and removed by histone lysine methyltransferases and demethylases, respectively. Lysine methylation occurs in a specific ...
Deciphering the biological functions of F-box proteins through the use of Parallel Adaptor Capture (PAC) proteomics.
(2013-10-18)
The timely and selective proteasomal degradation of proteins is important for the maintenance of proper cellular processes. Prior to proteasomal degradation, proteins destined for degradation are polyubiquitiylated by ...
Integrated Analysis of Patterning, Morphogenesis, and Cell Divisions in Embryonic Development by in toto Imaging and Quantitative Cell Tracking
(2013-10-18)
Patterning, morphogenesis, and cell divisions are distinct processes during development yet are concurrent and likely highly integrated. However, it has been challenging to investigate them as a whole. Recent advances in ...
Human Vascular Endothelium from Induced Pluripotent Stem Cells
(2013-10-08)
The vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. The development ...
Mechanisms Governing Mesothelial Clearance by Ovarian Cancer Spheroids
(2013-10-08)
Metastatic dissemination of ovarian tumors involves the invasion of multi-cellular tumor cell clusters into the mesothelial cell lining of organs in the peritoneal cavity. We developed an in vitro assay that models this ...
Regulation of excitatory synapse development by the RhoGEF Ephexin5
(2013-10-18)
The neuronal synapse is a specialized cell-cell junction that mediates communication between neurons. The formation of a synapse requires the coordinated activity of signaling molecules that can either promote or restrict ...
Regulation of Gli proteins by the Hedgehog Signaling Pathway
(2013-10-17)
Hedgehog signaling is essential during embryogenesis and in the maintenance of adult
Functional Genomics Approaches to Identify and Characterize Oncogenic Signaling
(2013-10-15)
Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and survival. Suppression of the driving oncogene is highly effective for promoting tumor regression, a phenomenon termed "oncogenic ...
Smoothened regulation in the Hedgehog signaling pathway
(2013-10-18)
Hedgehog signaling is a pathway essential in embryonic development, adult stem cell maintenance, and is implicated in the formation and progression of cancer. Signaling in this pathway is triggered when the secreted protein ...
Physiological and Pharmacological Regulation of the STAT3 Pathway in Cancer
(2013-10-18)
STAT3 is a critical oncogenic transcription factor, but how it becomes aberrantly activated in cancer is unclear. We have discovered a new pathway whose loss is associated with persistent STAT3 activation in human cancer. ...