Now showing items 1-10 of 32
Cellular and Systemic Metabolic Adaptations to Energy Status
My thesis work has focused on physiological adaptations to nutrient stress; from genes, environment and hormonal perspective, and how failure of these systems result in common chronic diseases.
Reprogramming Pediatric Genetic Disorders: Pearson Syndrome, Ring 14 Syndrome, and Fanconi Anemia
The effect of a single genetic mutation can vary greatly between different types of cells. The mutated gene may not be expressed in one tissue but may cause a devastating loss of function in another. To learn about disease ...
Investigating Synthetic Lethal Interactions with the Wall Teichoic Acid Pathway of Staphylococcus aureus
The peptidoglycan of many Gram-positive bacteria is densely functionalized with anionic glycopolymers called wall teichoic acids (WTAs). Recent studies have shown that these polymers play crucial roles in cell shape ...
Thyroid Hormone and Insulin Metabolic Actions on Energy and Glucose Homeostasis
Faced with an environment of constantly changing nutrient availability, mammals have adapted complex homeostatic mechanisms to maintain energy balance. Deviations from this balance are largely corrected through a concerted, ...
Exploring the role of microRNAs in airway smooth muscle biology and asthma therapy
The pathophysiology of asthma is characterized by airway inflammation, remodeling and hyper-responsiveness. Phenotypic changes in airway smooth muscle cells (ASM) play a pivotal role in the pathogenesis of asthma. ASM cells ...
Elucidating the virulence control network in Francisella tularensis
The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia and a model intracellular pathogen. It is also considered a potential bioweapon, as F. tularensis is highly infectious and has the ...
Dietary Restriction-Induced Longevity in Caenorhabditis elegans: Mediated by Stress Defense, NAD\(^+\)-Dependent Mechanisms and a Respiratory Shift
Dietary restriction (DR), or the reduction of food consumption without malnutrition, is the most conserved method of preventing or reversing age associated diseases. It is also the most conserved method of increasing ...
Genome-wide Analysis of Ctcf-RNA Interactions
Ctcf is a "master regulator" of the genome that plays a role in a variety of gene regulatory functions as well as in genome architecture. Evidence from studying the epigenetic process of X-chromosome inactivation suggests ...
From DNA sequence recognition to directional chromosome segregation: Information transfer in the translocase protein SpoIIIE
Faithful chromosome segregation is essential for all living organisms. Bacterial chromosome segregation utilizes highly conserved directional SpoIIIE/FtsK translocases to move large DNA molecules between spatially separated ...
Modeling sporadic Alzheimer's disease using induced pluripotent stem cells
Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation ...