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Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
(2016-05-14)
Despite its eponymous association with proteotoxic stress, heat shock factor 1 (Hsf1 in yeast and HSF1 in mammals) is required for viability of yeast and many human cancer cells, yet its essential role remains undefined. ...
Combinatorial Pathway Modulation Toward Ex Vivo Maintenance and Propagation of Hematopoietic Stem Cells
(2016-05-18)
Hematopoietic stem cells (HSCs) sustain continuous turnover and maintenance of all blood lineages through organismal lifespan. The extensive regenerative potential of HSCs has been harnessed in transplantation medicine ...
Transcriptional Control of Maternal-Fetal Immune Tolerance
(2016-05-18)
Human leukocyte antigens (HLA) are important determinants of self-nonself immune recognition. HLA-G, uniquely expressed in the placenta, is believed to be key to fetus-induced immune tolerance during pregnancy. The ...
Resistance to Targeted Therapy in Sonic Hedgehog Subgroup Medulloblastoma: Mechanisms and Treatment Strategies
(2016-05-17)
Aberrant activation of the Sonic Hedgehog (Shh) signaling network is implicated in many human cancers, including the most common cancer, basal cell carcinoma (BCC) and the brain tumor medulloblastoma. Suppressing Shh ...
Cell Shape and Treatment Duration: How They Influence a Cancer Cell's Response to TNF
(2016-05-17)
The purpose of my research was to investigate the sources of heterogeneity in cellular decisions that are based on both external and internal cues. I used the signaling network induced by tumor necrosis factor (TNF) as a ...
A New Active Cell Culture Material for Controlled Cell Micro-Manipulation
(2016-05-14)
Mechanical forces in the cell’s natural environment have a crucial impact on growth and behavior, from single-cell gene expression and cell division to the spatial patterning of complex organ architectures. Few areas of ...
Neurotoxic Mechanisms of the Chemotherapeutic Paclitaxel
(2016-05-04)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of multiple chemotherapeutic agents for which there are currently no prevention strategies. The widely used chemotherapeutic paclitaxel ...
Isogenic Human Pluripotent Stem Cell Models of Cardiovascular Disease-Associated Genetic Variation
(2016-03-30)
A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ...
Regulation of Mitochondrial Distribution and Inheritance During Cell Division
(2016-05-13)
Mitochondria are crucial to the cell and perform numerous functions including generating cellular ATP, buffering calcium, and creating macromolecules. Mitochondria contain their own DNA and as such, cannot be synthesized ...
A Field Guide to The Limb Progenitor
(2016-05-16)
The primary goal of this thesis was to characterize the embryonic limb progenitor, a cell type that populates the early limb bud during the onset of limb morphogenesis. Two features of the limb progenitor were explored 1) ...