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Loss of Insulin Receptor Substrates 1 and 2 Suppresses Kras-Driven Non-Small Cell Lung Cancer
(2017-07-06)
Lung cancer remains the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) being the majority of diagnosed cases of lung cancer. Mutant KRAS is found in about 25% of all NSCLC and has proved ...
In Vivo Genetic Screening to Identify Mechanisms of Resistance to Cancer Immunotherapy
(2017-10-10)
Despite the dramatic clinical success of cancer immunotherapy with PD-1 checkpoint blockade, most patients do not experience sustained clinical benefit from treatment, suggesting that additional therapeutic strategies are ...
Genetic and genomic approaches to understand size and proportion
(2017-01-10)
The establishment of proper proportions during development is essential for the final form and function of an organism. While much is known concerning the regulation of proliferation and differentiation, how the relative ...
Molecularly Distinct, Meissner-Corpuscle-Associated Mechanoreceptors: A Potential Strategy for Efficient Enhancement of Spatial Acuity
(2017-09-08)
Tactile perception involves a diverse cadre of receptor types that extract distinct but often overlapping features of mechanical forces impinging on the skin. The stimulus features that a receptor responds to can reveal a ...
Investigations Into DNA Double Strand Breaks in Neural Development and Function
(2017-05-12)
Genomic integrity is dependent on the repair of DNA double-strand breaks (DSBs) by classical non-homologous end-joining (C-NHEJ). C-NHEJ is essential for suppressing aberrant chromosomal rearrangements, and is also critical ...
Extrinsic and Intrinsic Factors Impacting Local Circuit Inhibition in the Neocortex
(2017-01-25)
Neuronal circuits controlling our perception and behaviors are radically shaped by experiences during early critical periods. For example, early life stress (ELS) has been linked to enduring negative behavioral consequences ...
The Regulatory Effects of Environmental Enrichment on Microglia in Health and in Alzheimer’s Disease Model Systems
(2017-05-15)
Microglial dysfunction is increasingly recognized as a key contributor to the pathogenesis of Alzheimer’s disease (AD). Environmental enrichment (EE) is well-documented to enhance neuronal form and function, but almost ...
Of Xist and Dosage Compensation in Mammalian Development and Disease
(2017-01-10)
In mammals, equalized gene dosage between the sexes is ensured by a process called X chromosome inactivation (XCI). XCI, mediated by the long noncoding RNA Xist, initiates early in female embryogenesis, both in extraembryonic ...
Elucidating the Role of RasGAP Genes as Tumor Suppressors in Breast Cancer
(2017-05-10)
RAS genes are commonly mutated in human cancers and aberrant Ras activation drives tumorigenesis. However, RAS mutations are rare in breast cancer, despite frequent hyperactivation of Ras and its effectors, suggesting that ...
Bacterial Virulence Regulation and Targets of CD8+ T Cell Immunity During Listeria monocytogenes Infection
(2017-09-08)
Listeria monocytogenes (Lm) is an intracellular bacterial pathogen that causes a severe invasive disease in humans. Upon infection, Lm must sense its presence within a host and upregulate bacterial genes necessary for ...