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Cyanobacteria and Friends: Engineered Photosynthetic Microbial Communities
(2017-02-10)
Microbial communities are the rule rather than the exception. Laboratories using model organisms often focus on monoclonal, axenic cultures overlooking the importance of the interactions, division of labor, and robustness ...
Genetic Engineering Toward a 57-Codon Genome
(2017-01-09)
Scientific progress in fundamental biology has drastically transformed our ability to engineer biological systems, with diverse applications in medicine and industry, from insulin and artemisin production in prokaryotes ...
Bacterial Virulence Regulation and Targets of CD8+ T Cell Immunity During Listeria monocytogenes Infection
(2017-09-08)
Listeria monocytogenes (Lm) is an intracellular bacterial pathogen that causes a severe invasive disease in humans. Upon infection, Lm must sense its presence within a host and upregulate bacterial genes necessary for ...
Clp-Mediated Regulation of the Mycobacterial Cell Cycle
(2017-04-12)
Tuberculosis is currently the most deadly infectious disease worldwide. Given the high rates of treatment failure, new antibiotics are desperately needed. Antibacterial drugs typically target DNA replication, cell growth, ...
Why WhiB1: Manipulation of Clp System to Determine Role of WhiB1 in Regulating Mycobacterial Cell Division
(2017-05-10)
Mycobacterium tuberculosis (Mtb) is the causal agent of tuberculosis (TB), a major public health issue in the world. In the 2015 WHO report, there were approximately 10.4 million new cases of TB worldwide and 1.4 million ...
Fitness Tradeoffs, Bimodality, and the Genetics of Natural Variation in Glucose-Galactose Sensing Across Saccharomyces Cerevisiae
(2017-01-26)
In nature, cells must constantly sense their environment and respond appropriately. These cellular “decisions” are implemented by molecular components that can mutate and evolve. How do mutations lead to changes in cellular ...
The Origin of Cell Fate Heterogeneity in Bacillus Subtilis
(2017-04-13)
A central question in biological development is how individual cells in a common environment are able to adopt distinct cell fates. In response to nutrient deprivation, Bacillus subtilis cells initiate the formation of a ...
Mechanisms of Bacterial Envelope Stress From Within and Without
(2017-01-25)
The bacterial cell envelope is the frontline protective barrier between the cell and the environment. It is a complex multilayered structure essential for maintaining cellular integrity and plays a crucial defensive role ...
The Role of MreB in Producing Rod-Shaped Bacterial Cells
(2017-09-08)
MreB, an actin homolog, is known to form short, membrane-associated filaments that move circumferentially in rod-shaped bacteria, in association with cell wall-synthesizing enzymes. Despite being essential for rod shape, ...
Biophysical Studies of the Lpt Pathway
(2017-07-06)
The outer membrane (OM) of Gram-negative bacteria is impermeable to many antibiotics because its outer leaflet is composed entirely of lipopolysaccharide (LPS), a large glycolipid with an extracellular saccharide that is ...