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Prevention of Relapses in Mice With Ongoing EAE via Combined Allogeneic Bone Marrow and Neural Stem Cell Transplantation
Multilineage mixed hematopoietic chimerism induces transplantation tolerance to allogeneic solid organ transplants in both animal models and humans. Yet we still have an imperfect understanding of the underlying mechanism ...
Commensal Microbiota-Induced Interferon-Beta Mediates Host Immune System Modulation and Natural Resistance to Virus Infection
The type I interferon (IFN-I) response is a crucial mediator of antiviral immunity and homeostatic immune system regulation. Despite this importance, the source of IFN-I signaling under homeostatic conditions has yet to ...
Uncovering the Pathology of Rheumatoid Arthritis With Single Cell Immunoprofiling
Rheumatoid arthritis (RA) is a chronic multi-systemic autoimmune disorder affecting nearly 25 million people worldwide, yet its underlying causes remain unclear. Genetic studies of patients with RA have highlighted the ...
Regulatory T Cell TGF-B1 Regulates Distinct Checkpoints Governing Allergy and Autoimmunity
The mechanisms by which regulatory T (Treg) cells differentially control allergic and autoimmune responses remain unclear. We show that Treg cells in food allergy (FA) have decreased expression of transforming growth factor ...