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CRISPR Activation Screening of Circulating Tumor Cells Identifies Enhancers of Blood-Based Metastasis
Over ninety percent of cancer mortality is attributable to metastasis, most commonly due to the blood-borne dissemination of cancer cells from a primary tumor to secondary tissues. However, the vast majority of these cancer ...
Exploiting Amino Acid Catabolism as a Metabolic Vulnerability in Breast Cancer
A growing tumor is faced with many challenges, including how to obtain and utilize nutrients. Reprogramming of metabolism has emerged as a hallmark of cancer and numerous studies have identified specific alterations in ...