Gene transcription by RNA polymerase II (RNAPII) is a tightly regulated process necessary for the development and growth of all eukaryotes. In addition to synthesizing RNA, RNAPII coordinates—through a variety of ...

In multicellular organisms, the Polycomb group (PcG) proteins play a significant role in maintaining the repression of specific target genes across development. There are five proteins in the mammalian Cbx family that can ...