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Genome-Wide Screen Identifies RTF2 as a Host Restriction Factor That Restricts Influenza A Virus Replication
Viral infection triggers the secretion of type I interferons, which in turn induce expression of hundreds of genes. However, the roles and molecular mechanisms of these induced genes in the context of antiviral immunity ...
Assembly of RIG-I Signaling Complexes in Antiviral Immunity
RIG-I is a cytosolic sensor of viral dsRNA. RIG-I molecules are recruited to and translocate along the length of the viral dsRNA, forming filaments. Filament formation initiates a signaling cascade that leads to the ...
Evolution and Regulation of Antiviral Nucleotide Signaling
Cells utilize diverse methods for detecting and responding to viral infection. In mammals, the enzyme cyclic GMP–AMP synthase (cGAS) binds directly to viral DNA in the cytosol and becomes activated to synthesize the ...