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Why WhiB1: Manipulation of Clp System to Determine Role of WhiB1 in Regulating Mycobacterial Cell Division
(2017-05-10)
Mycobacterium tuberculosis (Mtb) is the causal agent of tuberculosis (TB), a major public health issue in the world. In the 2015 WHO report, there were approximately 10.4 million new cases of TB worldwide and 1.4 million ...
The Origin of Cell Fate Heterogeneity in Bacillus Subtilis
(2017-04-13)
A central question in biological development is how individual cells in a common environment are able to adopt distinct cell fates. In response to nutrient deprivation, Bacillus subtilis cells initiate the formation of a ...
The Role of MreB in Producing Rod-Shaped Bacterial Cells
(2017-09-08)
MreB, an actin homolog, is known to form short, membrane-associated filaments that move circumferentially in rod-shaped bacteria, in association with cell wall-synthesizing enzymes. Despite being essential for rod shape, ...
A Clock-Phased Sigma Factor Cascade Is Required for Global Circadian Transcriptional Rhythms in Cyanobacteria
(2017-09-07)
The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 drives oscillations in global mRNA transcript abundances with 24 h periodicity under continuous light conditions. The transcription factor RpaA ...
Circadian Clocks in the Real World: Effects of Dynamic Light Regimes on the Regulation of Circadian Gene Expression in Cyanobacteria
(2017-09-13)
Organisms use internal oscillators to control their physiology in conjunction with the predictable environmental changes of the day/night cycle. However, it is not always clear how internal timing information is used by ...
Flagellar Biosynthesis in E.coli Is Regulated by a Cascade of Stochastic Pulses
(2017-01-20)
Genetically identical populations of bacteria can exhibit significant phenotypic heterogeneity even in the absence of environmental variations. In bacteria such as Bacillus and Salmonella, flagellar motility has been found ...
Investigating Extracellular DNA Release in Staphylococcus Aureus Biofilm Formation
(2017-01-25)
Staphylococcus aureus is a leading cause of nosocomial infections in the United States, and isolates of this pathogen are capable of forming biofilms through different mechanisms. Biofilm formation reduces susceptibility ...