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Modeling Rare Protein-Coding Variation to Identify Mutation-Intolerant Genes With Application to Disease
Sequencing exomes—the 1% of the genome that codes for proteins—has increased the rate at which the genetic basis of a patient’s disease is determined. Unfortunately, when a patient does not carry a well-established pathogenic ...
Molecular Patterns and Signatures of Longevity
Since their divergence from a common ancestor some 200 million years ago, mammals have undergone significant diversification in physiology, morphology, habitat, size, and longevity. The maximum lifespan of mammalian species ...