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Structural and Functional Studies Into Nramp Divalent Metal Transporter Mechanisms
(2015-07-10)
The Nramp (natural resistance associated macrophage protein) family of transition metal ion transporters is an important class of secondary active transporters involved in metal homeostasis used by all branches of life. ...
Neutralizing Antibodies to Epstein Barr Virus in the Rhesus Macaque Animal Model and in Humans
(2015-08-07)
Epstein-Barr virus (EBV) is associated with a number of human diseases and does not have a vaccine. It is believed that neutralizing antibodies are an important immune effector for an EBV vaccine, but it is unknown whether ...
The Molecular Determinants of Cranial Skeletal Development and Evolution
(2015-10-01)
The vertebrate head and face, one of the defining features of vertebrates, is an evolutionary novelty that enabled the major radiation of Vertebrata. The emergence of the multipotent neural crest cells, often mentioned as ...
Dynamics of Neural Activity During Chemotaxis in Caenorhabditis Elegans
(2015-09-28)
The nervous system of an animal must control and coordinate locomotion in a changing and often unpredictable environment in order to survive. When a Caenorhabditis elegans navigates its environment, the nervous system can ...
Rabies Glycoprotein-Mediated Uptake Into Epithelial Cells and Compartmentalized Primary Neuronal Culture
(2015-09-29)
Rabies virus (RABV) subverts host neuronal circuitry to gain access to the brain where it causes generally incurable, lethal encephalitis. The single glycoprotein (G) dictates two defining steps for infection and neuroinvasion: ...
Evolving Models of Ovarian Cancer: Defining the Role of PAX8 in Fallopian Tube Tumorigenesis
(2015-08-07)
Ovarian cancer is the most deadly gynecological malignancy in the US. Once thought to be a single disease arising from the ovarian surface epithelium, we now understand that it is in fact a heterogenous disease with origins ...
A Rapid Peak in Gamma Power Signals Critical Period Plasticity in the Developing Mouse Visual Cortex
(2015-09-01)
Experience sculpts neural circuits during discrete windows of postnatal development termed critical periods. This process allows the brain to adapt to its environment and efficiently allocate resources. However, maladaptive ...
Activity Dependent Regulation of Inhibitory Circuitry
(2015-10-02)
Inhibition controls information flow through a neural circuit by modulating synaptic
integration, restricting action potentials, and coordinating the activity of ensembles of
neurons. These functions are mediated by a ...
A Structural and Functional Investigation of Germ Plasm Organization Mediated by D. Melanogaster Oskar Protein
(2015-09-25)
Germ cells are the unique source of gametes for multicellular organisms and are specified through different mechanisms. One such specification mechanism is inheritance-mediated, in which the molecular factors necessary and ...
The Discovery and Characterization of the lncRNA Firre
(2015-05-08)
RNAs, including long noncoding RNAs (lncRNA), are known to be abundant and important structural components of the nuclear infrastructure. Yet, the identities, functional roles, and localization dynamics of lncRNAs that ...