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Dynamics of Neural Activity During Chemotaxis in Caenorhabditis Elegans
(2015-09-28)
The nervous system of an animal must control and coordinate locomotion in a changing and often unpredictable environment in order to survive. When a Caenorhabditis elegans navigates its environment, the nervous system can ...
A Rapid Peak in Gamma Power Signals Critical Period Plasticity in the Developing Mouse Visual Cortex
(2015-09-01)
Experience sculpts neural circuits during discrete windows of postnatal development termed critical periods. This process allows the brain to adapt to its environment and efficiently allocate resources. However, maladaptive ...
Activity Dependent Regulation of Inhibitory Circuitry
(2015-10-02)
Inhibition controls information flow through a neural circuit by modulating synaptic
integration, restricting action potentials, and coordinating the activity of ensembles of
neurons. These functions are mediated by a ...
Roles of Retinal Circuits in the Innate Visual Behaviors of Mice
(2015-05-01)
Much of brain science is concerned with understanding the neural circuits that underlie specific behaviors. While the mouse has become a favorite experimental subject, the behaviors of this species are still poorly explored, ...
Neuromodulatory Control of Motivated Behavior in the Larval Zebrafish
(2016-05-06)
An animal’s behavior is strongly influenced by homeostatic drives that are crucial for survival and reproduction, such as the drive to eat, or to escape from harmful threats. In vertebrates, an evolutionarily ancient brain ...
Neural Mechanisms Underlying the Establishment of Unimodality in Mouse Primary Visual Cortex
(2016-01-27)
Early visual cortex, an area classically defined as a purely unisensory cortex, has been suggested to be influenced by non-visual sensory inputs (Wallace et al., 2004; Iurilli et al., 2011; Vasconcelos et al., 2011; ...
Morphological, Physiological and Molecular Classification of Mouse Retinal Ganglion Cells
(2016-01-15)
Visual information is conveyed from the retina to the brain through axons of retinal ganglion cells (RGCs). There are >20 different subtypes of RGCs, each of which detects specific features. Classification of RGC subtypes ...
Dissection of Complex Behavior and Whole-Brain Functional Mapping in Larval Zebrafish
(2016-09-12)
Understanding how the brain transforms sensory input into complex behavior is a fundamental question in systems neuroscience. Using larval zebrafish, we study the temporal component of phototaxis, ...
Genomic Imprinting in the Brain: the persistent influences from Mom and Dad
(2015-05-20)
Most mammalian genes are equally expressed from the two inherited parental alleles. However, a puzzling subgroup known as imprinted genes are preferentially expressed from either the maternally- or paternally-inherited ...
Motion Processing in the Larval Zebrafish Tectum
(2015-05-14)
Larval zebrafish are highly visual animals that display a diverse repertoire of visually guided behaviors. Five days after their birth, they start tracking and hunting moving prey, a behavior that likely requires underlying ...