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Development and Deployment of Optical Instruments to Measure Trace Atmospheric Species: I. Water Isotopologues; II. Glyoxal; III. Iodine Monoxide
(2012-12-13)
Understanding future climate requires observations of trace species that can significantly influence the chemical or radiative properties of the atmosphere. The development of optical instruments, utilizing laser-systems ...
Progress toward the Total Synthesis of Lomaiviticins
(2012-12-20)
A synthetic plan for the dimeric diazobenzofluorene natural product lomaiviticin A and lomaiviticin B is presented. The route features a late-stage oxidative enolate dimerization of a monomeric oxanorbornanone, as well as ...
Studies on Application of Silyl Groups in Ring-Closing Metathesis Reactions and Fragment-Based Probe Discovery
(2012-12-19)
In efforts to search for tool compounds that are capable of probing normal and disease-associated biological processes, both quality and identity of the screening collection are very important. Towards this goal, ...
Synthesis of Cortistatin Alkaloids and a Versatile Synthesis of Isoquinolines
(2012-08-10)
The cortistatins are a recently identified class of marine natural products that were found to exhibit potent and selective inhibition of human umbilical vein endothelial cells (HUVECs), making them promising leads for the ...
Chemical Vapor Deposition of Thin Film Materials for Copper Interconnects in Microelectronics
(2012-07-24)
The packing density of microelectronic devices has increased exponentially over the past four decades. Continuous enhancements in device performance and functionality have been achieved by the introduction of new materials ...
Metal-Ligand Multiple Bonds in High-Spin Complexes
(2012-07-23)
The chemistry of late first row transition metals supported by dipyrromethane and dipyrromethene ligands bearing sterically bulky substituents was explored. Transition metal complexes (Mn, Fe, Co, Ni, Zn) of the dipyrromethane ...
Silver-Mediated Trifluoromethoxylation of Aryl Nucleophiles and Synthesis of 3-Deoxy-3-Fluoromorphine
(2012-11-14)
Fluorine incorporation has become increasingly important in pharmaceutical applications. Upon fluorination and incorporation of fluorinated moieties such as trifluoromethoxy groups, many small molecules become more ...
Studies towards a Solution Structure of the Peptidoglycan Glycosyltransferases
(2012-09-13)
Peptidoglycan glycosyltransferases (PGTs) are highly conserved bacterial enzymes that catalyze the polymerization of the lipidic disaccharide, Lipid II, to form individual peptidoglycan (PG) strands which are subsequently ...
Magnetism, Reactivity and Metal Ion Lability in Trigonal Iron Clusters
(2012-09-12)
Important reactions are catalyzed by enzymes employing polynuclear cofactors, often characterized by weak-field ligands and transition metal ions within the sum of the van der Waals radii. While the overall stoichiometries ...
Chemical and Cellular Defenses against Foreign Pathogens
(2012-09-07)
Bacterial and viral infections affect billions of people each year. While bacterial infections are treated by the use of antibiotics, viral infections are eradicated by the immune system. This thesis comprises two parts. ...