Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...

In Chapter 1, we describe a general strategy for 1,3-oxidation of cyclopropanes using aryl iodine(I–III) catalysis, with emphasis on 1,3-difluorination reactions. These reactions make use of practical, commercially available ...

Despite decades of research in both biomimetic and abiological metal cluster synthesis, systematic control of the electronic structure of molecular metal clusters remains a significant challenge. This challenge stems in ...

The ability to carry out stable chronic mapping and manipulation of single neurons at the action potential level with high temporal resolution could significantly benefit both fundamental neuroscience research and biomedical ...

First-row transition metals find growing applications in organic transformations due to their abundance and low cost. In addition, the difference in redox states of first-row metals to those of second or third row metals ...

Atmospheric oxidation of volatile organic compounds (VOCs) leads to the formation of ozone (O3) and secondary organic aerosol (SOA), known atmospheric pollutants. These compounds have been shown to have negative health ...

Artificial photosynthesis is the electrochemical decomposition of water into oxygen and hydrogen driven by solar energy, allowing for the storage of solar energy in chemical bonds. Integrated photoelectrochemical cells ...

Solar power is a promising contender to replace fossil fuels with its inexhaustible supply and relatively low cost. Energy storage remains the missing link between intermittent solar supply and on-demand energy output. ...

Genome sequence and expression are highly dynamic. Understanding the forces that drive these changes is an important step in rationalizing the connection between an organism’s genome and its phenotype This thesis focuses ...

Genome editing technologies, such as the recently discovered CRISPR/Cas9 system, allow the researcher to site-specifically modify genes of interest in living cells and organisms, and have the potential to yield new ...