Search
Now showing items 1-10 of 35
Exploring Machine Learning Applications to Enable Next-Generation Chemistry
(2019-01-16)
As global demand for energy and materials grow while our dependence on petroleum and fossil fuels declines, it is necessary to revolutionize the way we make new materials. Machine learning provides several avenues for ...
Correlating Physical and Electronic Structure in Trinuclear Iron Clusters
(2019-05-07)
The study of biological nitrogen fixation carried out by the nitrogenase enzyme is of scientist interest in order to propose alternatives to the high-energy Haber Bosch process performed industrially. Nitrogenase contains ...
Deciphering Transcriptome: Transcription Factors as Master Mind Behind Gene Expression
(2019-08-15)
Transcription Factors (TFs) are key players in orchestrating diversified transcriptomes across cell types. Known to function in co-operative pairs, TFs are dynamic and hard to be experimentally captured in motion. With an ...
DNA Recombinases as Genome Editing Tools
(2019-04-29)
Site-specific recombinases (SSRs) have the potential to serve as ideal genome editing agents because they catalyze precise and efficient DNA strand exchange, but their innate specificity limits their applicability to a ...
High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)
(2019-05-14)
Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme responsible for the methylation of nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). NNMT overexpression has been linked to diabetes, obesity, and ...
In Search of Primordial RNA: The Effects of Noncanonical Nucleotides on Nonenzymatic Primer Extension
(2019-09-10)
The observation that the cellular machinery comprised of DNA, RNA, and proteins is more or less preserved across all terrestrial life evokes the thought that all life may stem from a unified origin. One of the many theories ...
Electrospun Polymer Nanofiber Scaffolds for Functionalized Long Sub-Micron Diameter Cables
(2019-05-17)
Utilization of thin, flexible, and conductive wires that are twisted in a bundle has significantly improved the performance of communication devices operating at MHz frequencies. For GHz frequency applications, available ...
Tracing Organic Complexity During Star and Planet Formation
(2019-05-16)
In this thesis, we use laboratory experiments and millimeter telescope observations to explore the origins of organic complexity in star- and planet-forming regions.
The laboratory experiments presented here test new ...
Electronic Structure of Open-Shell, First-Row Transition Metal Complexes for C–H Functionalization
(2019-08-05)
The electronic and steric factors that enable the isolation of open-shell iron dipyrromethene compounds containing ligand-centered radicals were explored. In addition to isolating these complexes, the relationship between ...
Convectively Induced Ozone Loss
(2019-05-08)
Tropopause-penetrating convection in the midlatitudes can induce ozone loss in the lower stratosphere through its unique ability to transport boundary layer air and moisture directly into the lower stratosphere, bypassing ...