Gram-negative bacterial infections are a worldwide problem and antibiotics capable of clearing such infections are an unmet clinical need. The polymyxins are highly potent drugs against Gram-negative bacteria but suffer ...

The development of efficient and selective routes for C–H amination is of interest as N–functionalities are an integral part of nature. To unveil essential attributes for facile C–H amination, the chemistry of cobalt ...

Natural products have historically provided a rich source of medicines, and natural product isolation and characterization continue to drive drug discovery and design. As the availability of genomic DNA sequences in public ...

This dissertation presents the development of new chemical vapor deposition (CVD) processes, with an emphasis on imparting desired properties to thin film layers for next-generation devices. To this end, two research areas ...

Small molecules—through their engagement with molecular targets—can be used to elucidate biological pathways, test therapeutic hypotheses, and treat human diseases. These compounds are often discovered via high-throughput ...

Iodine(III) catalysis has emerged as an effective strategy for enabling a wide range of alkene difunctionalization reactions. In Chapter 1, we describe the development of an enantioselective 1,2-difluorination of cinnamamides ...

Geometric barcoding has shown promise in fluorescence imaging applications for multiplexed, specific and sensitive detection of single molecules. This dissertation presents a super-resolution geometric barcoding scheme, ...

The conversion of abundant yet unreactive molecules to higher-value and more energy dense products by bioinorganic or inorganic materials systems typically proceeds through fleeting high energy intermediates whose physical ...

Bioelectronics explores the use of electronic devices for applications in signal transduction at their interfaces with biological systems. Ultra-flexible nano- and micro-scale bioelectronic systems have enabled seamless ...