The observation that multi-electron activation of small molecule substrates occurs at polynuclear reaction sites, common to both metalloenzymes and heterogeneous catalysts, has led to the articulation of the polynuclear ...

Kinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed ...

Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two ...

Palladium is one of the most common and versatile transition metals used in modern organometallic chemistry. The chemistry of palladium in its 0, +II, and +IV oxidation states is well-known; by comparison, the chemistry ...

Advances in optical imaging techniques have allowed quantitative studies of many biological systems. This dissertation elaborates on our efforts in both developing novel imaging modalities based on detection of optical ...

Small molecules play important roles in therapeutics and drug discovery. Significant progress has been made by the chemical biology community to discover small-molecule probes to explore biological processes and to treat ...

Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) are techniques widely utilized by many scientific fields, but their applications are often limited by short spin relaxation times and low ...

Selective 1,2-hydrosilylation of 1,3-dienes is a challenging problem to solve for transition metal catalysis. Butadiene, specifically, would be a useful substrate because 3-butenylsilane products have promise as superior ...

With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted ...

The C-H amination and olefin aziridination chemistry of iron supported by dipyrromethene ligands (RLAr, L=1,9-R2-5-aryldipyrromethene, R = Mes, 2,4,6-Ph3C6H2, tBu, Ad, 10-camphoryl, Ar = Mes, 2,4,6-Cl3C6H2) was explored. ...