Search
Now showing items 1-10 of 26
Multi-Electron Reduction of Small Molecules by Triiron Reaction Sites
(2013-10-15)
The observation that multi-electron activation of small molecule substrates occurs at polynuclear reaction sites, common to both metalloenzymes and heterogeneous catalysts, has led to the articulation of the polynuclear ...
Design and synthesis of dynamically assembling DNA nanostructures
(2014-02-25)
Kinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed ...
I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides
(2014-02-25)
Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two ...
Synthesis, Structure, and Reactivity of New Palladium(III) Complexes
(2014-06-06)
Palladium is one of the most common and versatile transition metals used in modern organometallic chemistry. The chemistry of palladium in its 0, +II, and +IV oxidation states is well-known; by comparison, the chemistry ...
Detection of Single-Molecule Optical Absorption at Room Temperature and Mechanistic Study of Transcriptional Bursting
(2014-06-06)
Advances in optical imaging techniques have allowed quantitative studies of many biological systems. This dissertation elaborates on our efforts in both developing novel imaging modalities based on detection of optical ...
Small-molecule probes to explore cancer
(2014-06-06)
Small molecules play important roles in therapeutics and drug discovery. Significant progress has been made by the chemical biology community to discover small-molecule probes to explore biological processes and to treat ...
Nuclear Magnetic Resonance with Spin Singlet States and Nitrogen Vacancy Centers in Diamond
(2014-06-06)
Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) are techniques widely utilized by many scientific fields, but their applications are often limited by short spin relaxation times and low ...
1,2-Selective Hydrosilylation of Conjugated Dienes
(2014-06-06)
Selective 1,2-hydrosilylation of 1,3-dienes is a challenging problem to solve for transition metal catalysis. Butadiene, specifically, would be a useful substrate because 3-butenylsilane products have promise as superior ...
Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors: Her3 and KRas
(2014-06-06)
With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted ...
C-H Amination Catalysis from High-Spin Ferrous Complexes
(2013-10-15)
The C-H amination and olefin aziridination chemistry of iron supported by dipyrromethene ligands (RLAr, L=1,9-R2-5-aryldipyrromethene, R = Mes, 2,4,6-Ph3C6H2, tBu, Ad, 10-camphoryl, Ar = Mes, 2,4,6-Cl3C6H2) was explored. ...