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Small-Molecule Modulators of Pancreatic Ductal Cells: Histone Methyltransferases and \(\beta\)-Cell Transdifferentiation
(2013-03-06)
Small molecules are important not only for treating human diseases but also for studying disease-related biological processes. This dissertation focuses on the effects of small molecules on pancreatic ductal adenocarcinoma ...
C-H Amination Catalysis from High-Spin Ferrous Complexes
(2013-10-15)
The C-H amination and olefin aziridination chemistry of iron supported by dipyrromethene ligands (RLAr, L=1,9-R2-5-aryldipyrromethene, R = Mes, 2,4,6-Ph3C6H2, tBu, Ad, 10-camphoryl, Ar = Mes, 2,4,6-Cl3C6H2) was explored. ...
Dynamic Hybrid Materials: Hydrogel Actuators and Catalytic Microsystems
(2013-09-30)
Dynamic materials which can sense changes in their surroundings and subsequently respond or adapt by autonomously altering their functionality, surface chemistry, transparency, color, wetting behavior, adhesiveness, shape, ...
Dissecting the Mechanisms of Direct Activation for Proapoptotic BAK and BAX
(2013-10-08)
Dissecting the Mechanisms of Direct Activation for Proapoptotic BAK and BAX
I. Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis II. Development of a Practical Method for the Synthesis of Highly Enantioenriched Trans-1,2-Amino Alcohols
(2013-08-21)
A highly enantioselective acylation of silyl ketene acetals with acyl fluorides was developed to generate useful α,α-disubstituted butyrolactone products in high yield and excellent enantioselectivities. This transformation ...
I. Engaging Cationic Intermediates in Asymmetric Catalysis: Enantioselective Reactions of Carbenium Ions and N,N-Dialkyliminium Ions II. Enantioselective Catalysis of the Cope-Type Hydroamination by H-Bond Donors
(2013-09-16)
The research described here explores the ability of dual H-bond donor catalysts to induce asymmetry in a variety of synthetically useful transformations that proceed via diverse reactive intermediates. In Chapters 1-3, ...
Unconventional Strategies to Target Challenging Enzymes Using Small-Molecule Covalent Inhibitors
(2013-10-08)
Unconventional strategies employing covalent small molecules were investigated to down-regulate signaling pathways mediated by enzymes that are challenging to target. First, Her3 was selectively degraded using covalent ...
Sensing Inorganic Phosphate Starvation by the Phosphate-Responsive (PHO) Signaling Pathway of Saccharomyces cerevisiae
(2013-09-30)
Inorganic phosphate \((P_i)\) is an essential nutrient whose intracellular levels are maintained by the PHO pathway in Saccharomyces cerevisiae. \(P_i\) limitation triggers upregulation of the PHO genes whose gene products ...
Total Synthesis of (−)-Nakadomarin A
(2013-10-18)
A convergent and scalable total synthesis of polycyclic manzamine alkaloid (-)-nakadomarin A is described. Unsaturated bicyclic lactam fragment A was prepared from acrolein in 5 steps, and macrolactam fragment B was prepared ...
First-Row Transition Metal Complexes of Dipyrrinato Ligands: Synthesis and Characterization
(2013-10-15)
A library of variously-substituted dipyrrins and their first-row transition metal (Mn, Fe, Cu, Zn) complexes have been synthesized, and the effects of peripheral substituents on the spectroscopic, electrochemical, and ...