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Integrated Stimuli-Responsive Functionalities: From Bioseparation to Dynamic Optics
(2016-05-04)
Nature demonstrates the efficiency of hierarchically integrated components that work in cooperation to produce a variety of useful phenomena in organisms, such as movement or shape change. A key feature of these components ...
Reactivity and Selectivity in Aryl C–H Functionalization by Electrophilic Radicals
(2016-05-04)
Two main challenges hinder the development of new, broadly useful C–H functionalization reactions: (1) most C–H bonds constitute part of the relatively inert backbone of an organic molecule, so it is difficult to elicit ...
Sol-Gel Chemistry of Inverse Opals
(2016-04-28)
Controlling nano to microscale structuration enables one to alter a material’s optical, wetting, mechanical, and chemical properties. Structuration on this scale can be formed from spherical building blocks; in particular, ...
A New Active Cell Culture Material for Controlled Cell Micro-Manipulation
(2016-05-14)
Mechanical forces in the cell’s natural environment have a crucial impact on growth and behavior, from single-cell gene expression and cell division to the spatial patterning of complex organ architectures. Few areas of ...
The Development of a Cell-Based Screen for Discovering Lipopolysaccharide Biogenesis Inhibitors
(2018-09-16)
Gram-negative bacteria are more difficult to kill than Gram-positive bacteria due to the presence of an outer membrane that prevents many antibiotics from reaching their cellular targets. The outer membrane is an asymmetric ...
Evolution of Diversely Functionalized Nucleic Acid Polymers
(2018-04-19)
Darwinian evolution gave rise to biopolymers with a myriad of folded structures and functions, as well as all the diverse life forms on earth that are supported by those molecules. Amazingly, the essence of molecular ...
Peptide-Assisted Nonenzymatic RNA Replication in Coacervate Droplets
(2016-09-14)
Life on earth may have first appeared in the form of a protocell capable of metabolism and containing a self-replicating informational polymer. This polymer was likely to have been RNA due to its ability to serve both as ...
Development of Small Molecule Kinase Degraders as Chemical Biology Probes and Cancer Therapies
(2018-09-20)
Advances in chemical biology provide immense benefits to human health through the discovery of new medicines and new scientific tools to study disease. I have contributed to the advancement of this field by developing a ...
Chemical Approaches to the Surface Engineering of Paper and Cellulose-Based Materials for Microfluidics, Electronics and Low-Cost Diagnostics
(2016-01-27)
Paper (and other cellulose-based materials such as cotton thread and fabrics) are underexploited as materials for the construction of “high-tech” and “lab-on-a-chip” devices. One major drawback of paper is its tendency to ...
Novel nanowire structures and devices for nanoelectronic bioprobes
(2015-04-29)
Semiconductor nanowire materials and devices provide unique opportunities in the frontier between nanoelectronics and biology. The bottom-up paradigm enables flexible synthesis and patterning of nanoscale building blocks ...