5-Fluorouracil is a broad-spectrum chemotherapeutic for cancer treatment. [18F]5-Fluorouracil, which contains the radioactive isotope fluorine-18, is a tracer for positron emission tomography (PET) imaging and has been ...

Quinones are organic oxidants that play important roles in biological contexts and find wide application in organic synthesis. They are known to be activated toward electron transfer through hydrogen bonding, which has ...

Two main challenges hinder the development of new, broadly useful C–H functionalization reactions: (1) most C–H bonds constitute part of the relatively inert backbone of an organic molecule, so it is difficult to elicit ...

The macrolide class of antibiotics has been widely used to treat bacterial infections for over 65 years. To date, all practical routes to clinically used macrolide antibiotics have relied on the chemical modification of ...

First-row transition metals find growing applications in organic transformations due to their abundance and low cost. In addition, the difference in redox states of first-row metals to those of second or third row metals ...

Solar and wind energies have been growing so fast that in many regions around the world they have become the cheapest source for electricity production. Nevertheless, as we rely increasingly on solar and wind energies, one ...

Efficient and faithful replication of genomic information is perhaps one of the most important hallmarks of cellular life. At some early point, such processes must have occurred in the absence of elaborate nucleic acid or ...

In Chapter 1, we report the observation that chiral squaramide hydrogen-bond (H-bond) donor catalysts act cooperatively with trialkylsilyl trifluoromethanesulfonates (silyl triflates) to promote enantioselective (4+3) ...

Palladium-catalysis is commonly used in the functionalization of aromatic rings, ranging from prefunctionalized substrates such as aryl metals or aryl (pseudo)halides to the direct functionalization of aromatic C–H bonds. ...

Anion-binding catalysis has emerged as a powerful principle for the development of highly enantioselective transformations. This strategy relies on the ability of dual hydrogen-bond donors to promote anion abstraction from ...