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Reactions of Diketones and N-Allenoyloxazolidinones Catalyzed by Metal-Bis(oxazoline) Complexes
(2013-02-25)
This dissertation describes the investigation of the utility of metal–bis(oxazoline) complexes in catalytic asymmetric reactions. The development of Cu(II)-catalyzed regio- and enantioselective additions of silylketenthioacetals ...
Pseudoephenamine: A Practical Chiral Auixiliary for Asymmetric Synthesis
(2013-02-25)
Pseudoephedrine has been used as a chiral auxiliary in diastereoselective alkylation reactions, providing easy access to enantiomerically enriched carboxylic acids, alcohols, ketones, and aldehydes. Because pseudoephedrine ...
Nanowire Architectures for Next-Generation Solar Cells and Photonic Devices
(2013-02-15)
This thesis presents the design and synthesis of nanowires (NW) with targeted and tunable optical properties. Moreover, we show how single and assembled NW devices can enable new photovoltaic (PV) and photonic platforms. ...
Metabolomics Strategies for Discovery of Biologically Active or Novel Metabolites
(2013-02-08)
Along with genes and proteins, metabolites play important roles in sustaining life. There remains much to be learned about the in vivo roles of metabolites. Metabolomics is a comparative tool to study global metabolite ...
Development and Deployment of Optical Instruments to Measure Trace Atmospheric Species: I. Water Isotopologues; II. Glyoxal; III. Iodine Monoxide
(2012-12-13)
Understanding future climate requires observations of trace species that can significantly influence the chemical or radiative properties of the atmosphere. The development of optical instruments, utilizing laser-systems ...
Progress toward the Total Synthesis of Lomaiviticins
(2012-12-20)
A synthetic plan for the dimeric diazobenzofluorene natural product lomaiviticin A and lomaiviticin B is presented. The route features a late-stage oxidative enolate dimerization of a monomeric oxanorbornanone, as well as ...
Synthesis of Cortistatin Alkaloids and a Versatile Synthesis of Isoquinolines
(2012-08-10)
The cortistatins are a recently identified class of marine natural products that were found to exhibit potent and selective inhibition of human umbilical vein endothelial cells (HUVECs), making them promising leads for the ...
Label-Free Optical Imaging of Chromophores and Genome Analysis at the Single Cell Level
(2012-11-01)
Since the emergence of biology as a quantitative science in the past century, a lot of biological discoveries have been driven by milestone technical advances such as X-ray crystallography, fluorescence microscopy and ...
Metal-Ligand Multiple Bonds in High-Spin Complexes
(2012-07-23)
The chemistry of late first row transition metals supported by dipyrromethane and dipyrromethene ligands bearing sterically bulky substituents was explored. Transition metal complexes (Mn, Fe, Co, Ni, Zn) of the dipyrromethane ...
Chemical Vapor Deposition of Thin Film Materials for Copper Interconnects in Microelectronics
(2012-07-24)
The packing density of microelectronic devices has increased exponentially over the past four decades. Continuous enhancements in device performance and functionality have been achieved by the introduction of new materials ...