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Development of New Tools for Single-Molecule Force Spectroscopy & The Application of these Tools to Mapping the Role of Force Directionality in the Actin Mechanome
(2015-09-28)
Actin filaments serve as a hub of focal adhesion-based mechanotransduction network in a wide variety of cell types. In this role filaments and networks of filaments are exposed to forces in a range of directions and ...
Exploring Biomolecular Interactions Through Single-Molecule Force Spectroscopy and Computational Simulation
(2016-04-11)
Molecular interactions between cellular components such as proteins and nucleic acids govern the fundamental processes of living systems. Technological advancements in the past decade have allowed the characterization of ...
Active dynamics of microtubule and motor protein networks
(2017-05-04)
Cellular components have the remarkable ability to self-organize in space and time into higher order structures necessary to carry out biological functions. One example of such a structure is the spindle apparatus, a ...