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Loss of Insulin Receptor Substrates 1 and 2 Suppresses Kras-Driven Non-Small Cell Lung Cancer
(2017-07-06)
Lung cancer remains the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) being the majority of diagnosed cases of lung cancer. Mutant KRAS is found in about 25% of all NSCLC and has proved ...
In Vivo Genetic Screening to Identify Mechanisms of Resistance to Cancer Immunotherapy
(2017-10-10)
Despite the dramatic clinical success of cancer immunotherapy with PD-1 checkpoint blockade, most patients do not experience sustained clinical benefit from treatment, suggesting that additional therapeutic strategies are ...
Inter-species interactions in microbial communities
(2017-11-28)
Microorganisms are omnipresent and exist as communities within and around the human body. These communities, regardless of location, may cause disease: dysbioses within the gut microbiota are associated with obesity and ...
Investigations Into DNA Double Strand Breaks in Neural Development and Function
(2017-05-12)
Genomic integrity is dependent on the repair of DNA double-strand breaks (DSBs) by classical non-homologous end-joining (C-NHEJ). C-NHEJ is essential for suppressing aberrant chromosomal rearrangements, and is also critical ...
Extrinsic and Intrinsic Factors Impacting Local Circuit Inhibition in the Neocortex
(2017-01-25)
Neuronal circuits controlling our perception and behaviors are radically shaped by experiences during early critical periods. For example, early life stress (ELS) has been linked to enduring negative behavioral consequences ...
Genetic Determinants and Epigenetic Effects of Pioneer Factor Occupancy
(2017-08-10)
Transcription factors (TFs) are the core drivers of gene regulatory networks that control developmental transitions and a complete understanding of how they access, alter and maintain specific gene expression patterns ...
Genetic and genomic approaches to understand size and proportion
(2017-01-10)
The establishment of proper proportions during development is essential for the final form and function of an organism. While much is known concerning the regulation of proliferation and differentiation, how the relative ...
Regulation of RIPK1 Dependent Apoptosis and Necroptosis
(2017-01-03)
RIPK1 is a Ser/Thr kinase critically involved in mediating multiple signaling pathways activated by TNFa. When cells are stimulated by TNFa, RIPK1 is rapidly recruited to the intracellular domain of TNFR1 to form the TNF-RSC ...
Molecularly Distinct, Meissner-Corpuscle-Associated Mechanoreceptors: A Potential Strategy for Efficient Enhancement of Spatial Acuity
(2017-09-08)
Tactile perception involves a diverse cadre of receptor types that extract distinct but often overlapping features of mechanical forces impinging on the skin. The stimulus features that a receptor responds to can reveal a ...
Post-Transcriptional Regulatory Mechanisms in the Control of Cell Identity
(2017-05-09)
Cell identity is shaped by complex gene expression programs, at the core of which lies the set of messenger RNAs (mRNAs) expressed in a given cell. While there is considerable knowledge about the involvement of mRNA ...